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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin b

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin b

Hypercholesterolemia 6 Dyslipidemia 5 Flushing 3 Intermittent Claudication|Peripheral Vascular Disease 2 Parkinson's Disease 2 Mitochondrial Myopathies 2 Peripheral Sensory Neuropathy of Different Etiologies 1 Coronary Heart Disease 1 Acute Low Back Pain 1 Head and neck squamous cell carcinoma (HNSCC) is the seventh 1 HIV 1 Pelvic Floor Disorders|Ureter; Kink 1

📋 Sample Trials

NCT00046267

Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected Patients

Completed

NCT00062556

Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in Patients With Intermittent Claudication

Completed · Phase 3

NCT00203476

A Prospective, Open Label Comparison of Ezetimibe, Niacin, and Colestipol as Adjunct Therapy in Lipid Reduction

Completed · Phase 4

📊 Sample Meta-Analyses

CRD42021275439

A meta-analysis on the association of vitamin B, D, and E levels with the progression and risk of Alzheimer's disease

Alzheimer's Disease, neurodegenerative disease, vitamin deficiency, mitigating r

CRD42016045972

Vitamin B for treating diabetic peripheral neuropathy [Cochrane Protocol]

The Cochrane Neuromuscular Disease Group

CRD42019135162

A systematic review and meta-analysis of the efficacy of vitamin B in the management of diabetic peripheral neuropathy

The most common complication of diabetes is peripheral neuropathy. This can mani

📚 Sample References

PMID 31710686

Niacin protects against abdominal aortic aneurysm formation via GPR109A independent mechanisms: role of NAD+/nicotinamide

Cardiovasc Res · 2020

PMID 32912104

Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages

Circ Res · 2020

PMID 33576879

Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT/mTOR and ERK1/2 signaling pathways

Cell Tissue Res · 2021

⚗️ All Ingredient data fields for Vitamin b

⚗️ Identity

Name

Vitamin b

Aliases / Synonyms

nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Aminicotin; Amixicotyn; Papulex

🧪 Chemistry

Molecular Weight

122.1270

LogP

0.1805

Drug-likeness

0.577

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CN=C1)C(=O)N

Isomeric SMILES

C1=CC(=CN=C1)C(=O)N

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

InChI

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

🔗 External References

HERB DB

HBIN048038 ↗

PubChem CID

936 ↗

DrugBank

DB00627 ↗

NPASS

NPC167400

HIT

C0245

SymMap

1678

TCMID

23193

TCM-ID

24231

🔍 Raw view — every non-empty column on this row (32 fields)

name

Vitamin b

common names

nicotinamide; niacinamide; 98-92-0; 3-Pyridinecarboxamide; pyridine-3-carboxamide; Nicotinic acid amide; vitamin PP; Aminicotin; Amixicotyn; Papulex

herb ingredient id

HBIN048038

canonical smiles

C1=CC(=CN=C1)C(=O)N

isomeric smiles

C1=CC(=CN=C1)C(=O)N

inchi

InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

inchikey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

mol wt

122.1270

num h acceptors

num h donors

mol logp

0.1805

num rotatable bonds

drug likeness

0.577

symmap mol id

1678

tcmid ingredient id

23193

tcm id ingredient id

24231

pubchem cid

936

drugbank id

DB00627

npass id

NPC167400

hit id

C0245

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Cardiovascular Diseases

group

Coronary Heart Disease

Polycystic Ovary Syndrome

syndrome

Retinal Vein Occlusion

syndrome

Mitochondrial Myopathies

Carotid Atherosclerosis

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT00046267 Niacin for Treatment of Elevated Cholesterol and Triglycerides in HIV-Infected P

→ HIV Infections|Hypercholesterolemia|Hypertriglycer

NCT00062556 Effect of Niacin ER/Lovastatin on Peak Walking Time & Claudication Onset Time in

→ Intermittent Claudication|Peripheral Vascular Dise

NCT00203476 A Prospective, Open Label Comparison of Ezetimibe, Niacin, and Colestipol as Adj

→ Hyperlipidemia|Hypercholesterolemia

NCT00246376 Diet, Exercise, Niacin, and Fenofibrate to Reduce Heart Disease Risk Factors in

→ Cardiovascular Diseases|Heart Diseases|HIV Infecti

NCT00271817 To Evaluate Ezetimibe/Simvastatin and Niacin (Extended Release Tablet) in Patien

→ Hypercholesterolemia

NCT00286234 Niacin, N-3 Fatty Acids and Insulin Resistance

→ Metabolic Syndrome|Hypertriglyceridemia

NCT00298909 Exercise Versus Niacin in Patients With Coronary Artery Disease (CAD) and Low Hi

→ Coronary Disease|Hypolipoproteinemia

NCT00304993 Study of Niacin and Rosiglitazone in Dysmetabolic Dyslipidemia

→ Metabolic Syndrome X|Insulin Resistance

NCT00345657 Efficacy Study of Extended-Release Niacin/Lovastatin Versus Usual Care

→ Hyperlipidemia|Mixed Hyperlipidemia|Dyslipidemia

NCT00378833 Tolerability of MK0524A Versus Niacin Extended-Release (0524A-054)

→ Hypercholesterolemia|Hyperlipidemia

NCT00479388 Study of Extended Release Niacin/Laropiprant on Lipids (0524A-067)

→ Primary Hypercholesterolemia|Mixed Dyslipidemia

NCT00493064 To Study the Effectiveness and Safety of Niacin and a Topical Steroid Eye Drop t

→ Retinal Vein Occlusion

📊 Meta-Analyses

11 · systematic review

CRD42021275439 A meta-analysis on the association of vitamin B, D, and E levels with the progre

→ Alzheimer's Disease, neurodegenerative disease, vi

CRD42016045972 Vitamin B for treating diabetic peripheral neuropathy [Cochrane Protocol]

→ The Cochrane Neuromuscular Disease Group

CRD42019135162 A systematic review and meta-analysis of the efficacy of vitamin B in the manage

→ The most common complication of diabetes is periph

CRD42019146727 Homocysteine, vitamin B6, B12 and folic acid in patients with dementia, and vita

→ Dementia is one of the most devastating chronic di

CRD42020189673 Impact of vitamin B 6, B 9 & B 12 supplementations on hyperhomocysteinemia i

→ In this meta-analysis, stroke condition will be as

CRD42021235040 Vitamin B status and its impact in postmenopausal women

→ Vitamin B plays an important role in maintaining t

CRD42021242629 A systematic review on the efficacy of vitamin B supplementation on diabetic per

→ Diabetic Peripheral Neuropathy (DPN) is a common c

CRD42021244403 Vitamin B and Parkinson Disease: a systematic review

→ Parkinson disease and its commorbidities (e.g. per

CRD42021261321 Association of Folate, Vitamin B 12 and Homocysteine with Head and Neck Squamous

→ Head and neck squamous cell carcinoma (HNSCC) is t

CRD42023394167 The Role of Vitamin B and Folic Acid in Treatment of Alzheimer’s disease: A Syst

→ This systemic review and meta-analysis aimed to st

CRD42023421930 B vitamins and risk of coronary heart disease: a systematic review and meta-anal

→ Coronary heart disease is one of the major cardiov

📚 PubMed References

9 · cited research

PMID 31710686 Niacin protects against abdominal aortic aneurysm formation via GPR109A independ

Cardiovasc Res

PMID 32912104 Niacin Attenuates Pulmonary Hypertension Through H-PGDS in Macrophages

Circ Res

PMID 33576879 Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland

Cell Tissue Res

PMID 33924461 The Role of GPR109a Signaling in Niacin Induced Effects on Fed and Fasted Hepati

Int J Mol Sci

PMID 34190232 Dietary niacin affects intestinal morphology and functions via modulating cell p

Food Funct

PMID 35320002 The niacin receptor HCAR2 modulates microglial response and limits disease progr

Sci Transl Med

PMID 35690118 Niacin mitigates blood-brain barrier tight junctional proteins dysregulation and

Prog Neuropsychopharmacol Biol Psychiatry

PMID 35955466 Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induc

Int J Mol Sci

PMID 36568082 Niacin exacerbates β cell lipotoxicity in diet-induced obesity mice through upre

Front Endocrinol (Lausanne)

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables