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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin b12

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin b12

Vitamin B 12 Deficiency 6 Vitamin B12 Deficiency 4 Healthy 3 Pregnancy 2 Vitamin B12 deficiency caused by inadequate absorption of vi 2 Stroke is one of the major public health problems and a lead 1 Vitamin B12 Nutritional Deficiency 1 Depression 1 Nowadays, diet seems to be more important for people. It’s r 1 Recurrent Aphthous Stomatitis 1 Cardiovascular Disease|Endothelial Dysfunction 1 Vitamin B 12 supplementation/ Mild Cognitive impairment 1

📋 Sample Trials

NCT00120484

Effects of Vitamin B12 on the Body's Internal Clock

Completed

NCT00235573

Evaluation of Holotranscobalamin as an Indicator of Vitamin B12 Absorption

Completed

NCT00350116

Topical Vitamin B12 in Chronic Plaque Psoriasis

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42015024471

Factors influencing the propensity to diagnose vitamin B12 deficiency: a systematic review

Vitamin B12 deficiency. Propensity of medical practitioners to prescribe treatme

CRD42012003492

Worldwide prevalence of vitamin B12 insufficiency during pregnancy: a systematic review and meta-analysis

Vitamin B12 insufficiency, pregnancy.

CRD42016049020

A systematic review of the use of Vitamin B12 in assisting recovery of sensory deficit following nerve injury

Sensory nerve injury

📚 Sample References

PMID 36010649

Vitamin B12 Attenuates Changes in Phospholipid Levels Related to Oxidative Stress in SH-SY5Y Cells

Cells · 2022

⚗️ All Ingredient data fields for Vitamin b12

⚗️ Identity

Name

Vitamin b12

Aliases / Synonyms

cyanocobalamin; 68-19-9; Cyanocob(III)alamin; DTXCID5024346; MFCD00151092; Cobalamin (1+); Cyanocobalamin;Cyanocob(III)alamin; CAS-68-19-9; NCGC00016302-01

🧪 Chemistry

Molecular Weight

1355.3880

LogP

3.4092

Drug-likeness

0.048

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]

Isomeric SMILES

CC1=CC2=C(C=C1C)N(C=N2)[C@@H]3[C@@H]([C@@H]([C@H](O3)CO)OP(=O)([O-])O[C@H](C)CNC(=O)CC[C@@]4([C@H]([C@@H]5[C@]6([C@@]([C@@H](/C(=C(/C7=N/C(=C\C8=N/C(=C(\C4=N5)/C)/[C@H](C8(C)C)CCC(=O)N)/[C@H]([C@]7(C)CC(=O)N)CCC(=O)N)\C)/[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]

InChIKey

FDJOLVPMNUYSCM-WZHZPDAFSA-L

InChI

InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;-1;+3/p-2/t31-,34-,35-,36-,37+,41-,52-,53-

🔗 External References

HERB DB

HBIN048040 ↗

PubChem CID

5311498 ↗

DrugBank

DB00115 ↗

TCMID

22540

TCM-ID

157

🔍 Raw view — every non-empty column on this row (29 fields)

name

Vitamin b12

common names

cyanocobalamin; 68-19-9; Cyanocob(III)alamin; DTXCID5024346; MFCD00151092; Cobalamin (1+); Cyanocobalamin;Cyanocob(III)alamin; CAS-68-19-9; NCGC00016302-01

herb ingredient id

HBIN048040

canonical smiles

isomeric smiles

inchi

inchikey

FDJOLVPMNUYSCM-WZHZPDAFSA-L

mol wt

1355.3880

num h acceptors

num h donors

mol logp

3.4092

num rotatable bonds

drug likeness

0.048

tcmid ingredient id

22540

tcm id ingredient id

157

pubchem cid

5311498

drugbank id

DB00115

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Carpal Tunnel Syndrome

Premature Ejaculation

phenotype

Vertigo

phenotype

Vitamin B 12 Deficiency

syndrome

Gestational Diabetes

phenotype

Malignant Mesothelioma

Sleep Disorders, Circadian Rhythm

group

📋 Clinical Trials

12 · subject of clinical study

NCT00120484 Effects of Vitamin B12 on the Body's Internal Clock

→ Sleep Disorders, Circadian Rhythm

NCT00235573 Evaluation of Holotranscobalamin as an Indicator of Vitamin B12 Absorption

→ Disorder of Vitamin B12

NCT00350116 Topical Vitamin B12 in Chronic Plaque Psoriasis

→ Chronic Plaque Psoriasis

NCT00541073 Pemetrexed, Cisplatin, and Vitamin B12 in Treating Patients With Mesothelioma of

→ Malignant Mesothelioma

NCT00641862 Randomized Trial of Vitamin B12 in Pregnant Indian Women

→ Pregnancy

NCT00693589 Effect of Homocysteine-Lowering Therapy With Folic Acid, Vitamin B12, and Vitami

→ Cardiovascular Disease|Endothelial Dysfunction

NCT00717730 Folic Acid and Vitamin B12 in Young Indian Children

→ Diarrhea|Pneumonia

NCT00730093 The Absorption of Vitamin B12 Among Healthy Pregnant Women

→ Pregnancy

NCT00730509 Effects of 5-Methyltetrahydrofolate and Vitamin B12 Supplemetation on Red Cell M

→ Cystic Fibrosis

NCT00826657 Vitamin B12 Supplementation Study

→ Vitamin B12 Deficiency

NCT00843453 Long-term Use of Proton Pump Inhibitors May Cause Vitamin B12 Deficiency in the

→ Vitamin B12 Deficiency

NCT01183065 Study of Pralatrexate With Vitamin B12 and Folic Acid Supplementation for Previo

→ Head and Neck Cancer

📊 Meta-Analyses

12 · systematic review

CRD42015024471 Factors influencing the propensity to diagnose vitamin B12 deficiency: a systema

→ Vitamin B12 deficiency. Propensity of medical prac

CRD42012003492 Worldwide prevalence of vitamin B12 insufficiency during pregnancy: a systematic

→ Vitamin B12 insufficiency, pregnancy.

CRD42016049020 A systematic review of the use of Vitamin B12 in assisting recovery of sensory d

→ Sensory nerve injury

CRD42018090140 Serum homocysteine, folate and vitamin B12 levels in patients with psoriasis: a

→ Patients with psoriasis and psoriatic arthritis.

CRD42018090254 Vitamin B12 and lung cancer: a dose-response meta-analysis

→ Lung cancer; vitamin B12.

CRD42018092552 Vitamin B12 and the risk of cancer: a meta-analysis of prospective studies

→ Cancer. Vitamin B12.

CRD42018093688 Serum homocysteine, folate and vitamin B12 levels in patients with vitiligo: a s

→ Patients with all types of vitiligo. Previous stud

CRD42018095299 Vitamin B12 and prostate cancer: a dose-response meta-analysis

→ Prostate cancer; vitamin B12.

CRD42019129973 Serum homocysteine, folate and vitamin B12 levels in patients with lupus erythem

→ Patients with all types of lupus erythematosus. In

CRD42019135823 Effectiveness of vitamin B12 on cognitive outcomes, depression and non-specific

→ Cognitive function, depressive symptoms, and non-s

CRD42020151010 The association between vitamin B12 status markers in mother-child paires: a sys

→ foetomaternal Health, child-maternal health

CRD42020152806 Vitamin B12 supplementation in women of reproductive age

→ The efficacy of vitamin B12 supplementation on vit

📚 PubMed References

1 · cited research

PMID 36010649 Vitamin B12 Attenuates Changes in Phospholipid Levels Related to Oxidative Stres

Cells

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables