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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
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Herb
6,826
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Ingredient
44,598
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🧬
Gene Target
15,695
→
🏥
Disease
30,467
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🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
⚗️ Ingredient
Vitamin b6
9
Clinical Trials
9
Meta-Analyses
4
PubMed References
Top Conditions Studied with Vitamin b6
Lung cancer. Vitamin B6 intake. 1
Cancer 1
Dementia is one of the most devastating chronic diseases in 1
ASD 1
Coronary heart disease is one of the major cardiovascular di 1
Colorectal cancer, currently the third most common cancer in 1
Vitamin B6 Deficiency 1
Sepsis|Vitamin B6|Kidney Injury|Inflammatory Response|Oxidat 1
Stroke is one of the major public health problems and a lead 1
Palmar-Plantar Erythrodysesthesia 1
Sorafenib is a multitargeted tyrosine kinase inhibitor, whic 1
Muscle Injury 1
📋 Sample Trials
NCT00693589
Effect of Homocysteine-Lowering Therapy With Folic Acid, Vitamin B12, and Vitamin B6 on Endothelium-Dependent Vasodilatation of Forearm Resistance Vessels in Patients With Coronary Heart Disease
Completed · Phase 2
NCT01128244
Vitamin B6 Effects for Women Taking Birth Control Pills
Completed · Phase 2|Phase 3
NCT02625415
The Topical Application of Vitamin B6 in Palmar-Plantar Erythrodysesthesia
Completed
📊 Sample Meta-Analyses
CRD42022340121
Effectiveness of Urea-Based Cream and Pyridoxine(vitamin B6) on Sorafenib-induced Hand-foot Syndrome/skin reaction in hepatocellular carcinoma patients: A Systematic Review and Meta-analysis
Sorafenib is a multitargeted tyrosine kinase inhibitor, which has been mainly us
CRD42018086377
Disodium cantharidinate and vitamin B6 injection adjunct with platinum-based chemotherapy for the treatment of advanced non-small-cell lung cancer: a meta-analysis and systematic review
Non-small-cell lung cancer
CRD42018086540
Vitamin B6 and lung cancer risk: a systematic review and meta-analysis
Lung cancer. Vitamin B6 intake.
📚 Sample References
PMID 31970902
Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced acute pneumonia in mice
J Cell Mol Med · 2020
PMID 32967056
Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosine-1-phosphate in a sphingosine-1-phosphate lyase-dependent manner
J Cell Mol Med · 2020
PMID 33255657
Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Model of Age-Related Macular Degeneration as Novel HIF Inhibitors
Int J Mol Sci · 2020
⚗️ All Ingredient data fields for Vitamin b6
⚗️ Identity
Name
Vitamin b6
Aliases / Synonyms
pyridoxal 5'-phosphate(2-); (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate; 124051-94-1; pyridoxal 5'-phosphate dianion; CHEBI:597326; Q27225781; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-); 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, ion (2-)
🧪 Chemistry
Molecular Weight
245.1270
LogP
-0.7466
Drug-likeness
0.546
Oral Bioavailability
61.5400
H-Bond Acceptors
7
H-Bond Donors
1
Rotatable Bonds
4
🔬 Structures
Canonical SMILES
CC1=NC=C(C(=C1O)C=O)COP(=O)([O-])[O-]
Isomeric SMILES
CC1=NC=C(C(=C1O)C=O)COP(=O)([O-])[O-]
InChIKey
NGVDGCNFYWLIFO-UHFFFAOYSA-L
InChI
InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2
🔗 External References
HERB DB
PubChem CID
CAS Number
DrugBank
NPASS
NPC8869
SymMap
808
TCMID
23116
TCMSP
MOL011440
🔍 Raw view — every non-empty column on this row (33 fields)
name
Vitamin b6
common names
pyridoxal 5'-phosphate(2-); (4-formyl-5-hydroxy-6-methylpyridin-3-yl)methyl phosphate; 124051-94-1; pyridoxal 5'-phosphate dianion; CHEBI:597326; Q27225781; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate dianion; 3-hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde 5-phosphate(2-); 4-Pyridinecarboxaldehyde, 3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-, ion (2-)
herb ingredient id
HBIN048045
canonical smiles
CC1=NC=C(C(=C1O)C=O)COP(=O)([O-])[O-]
isomeric smiles
CC1=NC=C(C(=C1O)C=O)COP(=O)([O-])[O-]
inchi
InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)/p-2
inchikey
NGVDGCNFYWLIFO-UHFFFAOYSA-L
mol wt
245.1270
num h acceptors
7
num h donors
1
mol logp
-0.7466
num rotatable bonds
4
drug likeness
0.546
ob score
61.5400
cas id
65-23-6
symmap mol id
808
tcmid ingredient id
23116
tcmsp ingredient id
MOL011440
pubchem cid
644168
drugbank id
DB00165
npass id
NPC8869
🏥 Linked Health Topics
2 · diseases via target pathways📋 Clinical Trials
9 · subject of clinical studyNCT00693589 Effect of Homocysteine-Lowering Therapy With Folic Acid, Vitamin B12, and Vitami
→ Cardiovascular Disease|Endothelial Dysfunction
NCT01128244 Vitamin B6 Effects for Women Taking Birth Control Pills
→ Vitamin B6 Deficiency
NCT02625415 The Topical Application of Vitamin B6 in Palmar-Plantar Erythrodysesthesia
→ Palmar-Plantar Erythrodysesthesia
NCT03580499 Vitamin B6 in Reducing Hot Flashes in Participants With Prostate Cancer Undergoi
→ Hot Flashes|Prostate Carcinoma
NCT04070391 Vitamin B6 Supplementation and Mood States in College Women Taking Oral Contrace
→ Depression
NCT04509401 Effects of High Dose of Vitamin B6 With Magnesium in Children With Autism Spectr
→ ASD
NCT00659269 A Randomized Phase III Study of Vitamins B6 and B12 to Prevent Chemotherapy-Indu
→ Cancer
NCT04874662 Nicotinamide (NAM) and Pyridoxine (Vitamin B6) on Muscle Regeneration ("Satellit
→ Muscle Injury
NCT06008223 Clinical Analysis of Vitamin B6 in Sepsis
→ Sepsis|Vitamin B6|Kidney Injury|Inflammatory Respo
📊 Meta-Analyses
9 · systematic reviewCRD42022340121 Effectiveness of Urea-Based Cream and Pyridoxine(vitamin B6) on Sorafenib-induce
→ Sorafenib is a multitargeted tyrosine kinase inhib
CRD42018086377 Disodium cantharidinate and vitamin B6 injection adjunct with platinum-based che
→ Non-small-cell lung cancer
CRD42018086540 Vitamin B6 and lung cancer risk: a systematic review and meta-analysis
→ Lung cancer. Vitamin B6 intake.
CRD42019146727 Homocysteine, vitamin B6, B12 and folic acid in patients with dementia, and vita
→ Dementia is one of the most devastating chronic di
CRD42022212316 A systematic review of the potential role of abnormal vitamin B6 levels in patie
→ Parkinson's disease
CRD42022352776 Association between vitamin B6 and the risk of colorectal cancer: a systemic rev
→ Colorectal cancer, currently the third most common
CRD42022355077 Efficacy of folic acid supplementation in combination with vitamin B12 and vitam
→ Stroke is one of the major public health problems
CRD42022384203 Efficacy of four antiemetic drugs (doxylamine alone, pyridoxine (vitamin B6) alo
→ Nausea and vomiting of pregnancy
CRD42023421930 B vitamins and risk of coronary heart disease: a systematic review and meta-anal
→ Coronary heart disease is one of the major cardiov
📚 PubMed References
4 · cited researchPMID 31970902 Vitamin B6 inhibits macrophage activation to prevent lipopolysaccharide-induced
J Cell Mol Med
PMID 32967056 Vitamin B6 prevents excessive inflammation by reducing accumulation of sphingosi
J Cell Mol Med
PMID 33255657 Rice Bran and Vitamin B6 Suppress Pathological Neovascularization in a Murine Mo
Int J Mol Sci
PMID 36355132 Vitamin B6 Inhibits High Glucose-Induced Islet β Cell Apoptosis by Upregulating
Metabolites
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables