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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin c

Open on HERB 2.0 ↗

Clinical Trials

124

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin c

The Cochrane Heart Group 2 Preterm birth is defined as birth after 20 and before 37 com 2 The Cochrane Acute Respiratory Infections Group 2 Sepsis|Septic Shock 2 Iron deficiency anemia (IDA) results from a progressive depl 2 Sepsis/ septic shock requiring vasopressor/ inotropic suppor 1 Obstructive sleep apnea 1 Coronavirus disease 2019 (COVID-19). 1 Metastatic Pancreatic Cancer|Terminal Cancer 1 Vitamin C has been reported to be effective in pain relief. 1 Sepsis is a life-threatening organ dysfunction caused by dys 1 Hypertension represents a global epidemic and it is strongly 1

📋 Sample Trials

NCT05183880

Bioavailability of Orally Ingested Vitamin C

Withdrawn

NCT05192213

Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock

Terminated · Phase 3

NCT05194189

Clinical Efficacy of Megadose Vitamin C in Sepsis

Recruiting · Phase 2

📊 Sample Meta-Analyses

CRD42018103860

Vitamin C in critically ill adult patients with sepsis

Vitamin C is an essential water-soluble vitamin that humans are not able to stor

CRD42020170648

Effect of combined vitamin C, hydrocortisone and thiamine for patients with septic shock: a systematic review and meta-analysis

Nowadays, the mortality rate of septic shock remains as high as 50%, so the new

CRD42020206950

Combination therapy of thiamine and vitamin C in treating patients with sepsis or septic shock: A systematic review and meta-analysis

Sepsis is a common yet complex disorder that remains one of the major causes of

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Vitamin c

⚗️ Identity

Name

Vitamin c

Aliases / Synonyms

l-ascorbic acid; ascorbic acid; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid; L(+)-Ascorbic acid

🧪 Chemistry

Molecular Weight

176.1240

LogP

-1.4074

Drug-likeness

0.385

Oral Bioavailability

13.3440

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C(C1C(=C(C(=O)O1)O)O)O)O

Isomeric SMILES

C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

InChIKey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

InChI

InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

SymMap

118

TCMID

23170

TCMSP

MOL001691

TCM-ID

154

🔍 Raw view — every non-empty column on this row (33 fields)

name

Vitamin c

common names

l-ascorbic acid; ascorbic acid; 50-81-7; L-ascorbate; Ascoltin; ascorbate; Ascorbicap; Cevitamic acid; L(+)-Ascorbic acid

herb ingredient id

HBIN048047

canonical smiles

C(C(C1C(=C(C(=O)O1)O)O)O)O

isomeric smiles

C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O

inchi

InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1

inchikey

CIWBSHSKHKDKBQ-JLAZNSOCSA-N

mol wt

176.1240

num h acceptors

num h donors

mol logp

-1.4074

num rotatable bonds

drug likeness

0.385

ob score

13.3440

cas id

50-81-7

symmap mol id

118

tcmid ingredient id

23170

tcmsp ingredient id

MOL001691

tcm id ingredient id

154

pubchem cid

54670067

drugbank id

DB00126

🏥 Linked Health Topics

1 · studied for these conditions (text bridge)

Cardiac Arrest

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT05183880 Bioavailability of Orally Ingested Vitamin C

→ Healthy

NCT05192213 Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock

→ Sepsis|Septic Shock

NCT05194189 Clinical Efficacy of Megadose Vitamin C in Sepsis

→ Sepsis|Septic Shock

NCT05612867 Low Dose Vitamin C in Burns >20% Compared to Previous Studies With High Dose Vit

→ Burns|Ascorbic Acid Deficiency|Burn Shock|Burn Deg

NCT05598619 Effect of Colon Delivered Vitamin C on Gut Microbiota and Related Health Biomark

→ Quality of Life

NCT05310760 Effectiveness of Vitamin C Supplementation in Treatment of Rickets

→ Nutritional Rickets|Bone Turnover Rate Disorder

NCT05810233 Effect of Vitamin C on Allergy Skin Test

→ Rhinitis, Allergic|Allergy

NCT05733078 Effect of Vitamin C Supplementation in Patients With Primary Hypothyroidism

→ Hypothyroidism|Primary Hypothyroidism|Vitamin C De

NCT05843617 Comparison of Bioavailability of Liposomal and Traditional Formulation of Vitami

→ Bioavailability of Vitamin C

NCT05975125 The Effect of Vitamin C for Iron Supplementation During Pregnancy With Risk of A

→ Vitamin C Anemia|Pregnancy Anemia

NCT05842395 Vitamin c Supplementation in the Prevention of CRPS Following Distal Radius Frac

→ Distal Radius Fracture|Vitamine c|Prophylaxis

NCT05694975 Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients.

→ Vitamin C|COVID-19 Pneumonia

📊 Meta-Analyses

12 · systematic review

CRD42018103860 Vitamin C in critically ill adult patients with sepsis

→ Vitamin C is an essential water-soluble vitamin th

CRD42020170648 Effect of combined vitamin C, hydrocortisone and thiamine for patients with sept

→ Nowadays, the mortality rate of septic shock remai

CRD42020206950 Combination therapy of thiamine and vitamin C in treating patients with sepsis o

→ Sepsis is a common yet complex disorder that remai

CRD42020209086 Efficacy of Vitamin C, Thiamine, Steroids for Treatment in Sepsis Patients: A Sy

→ Sepsis or septic shock: Sepsis is an inflammatory

CRD42020216665 Benefit of hydrocortisone, thiamine, and vitamin C for patients with sepsis or s

→ Sepsis/ septic shock requiring vasopressor/ inotro

CRD42020220036 The Effectiveness of One or Combination of Vitamin C or Thiamine or Hydrocortiso

→ Description of The Condition Sepsis, if unable to

CRD42021244074 Intravenous vitamin C in critically ill patients: a systematic review and meta-a

→ Adult critically ill patients

CRD42022323880 The effect of intravenous Vitamin C monotherapy in critically ill patients. A sy

→ critical illness, Vitamin C

CRD42022342364 Intravenous vitamin C in critically ill patients with Sepsis : a systematic revi

→ Adults with Sepsis in the Intensive Care Unit

CRD42022318388 Vitamin C, Vitamin E, β-carotene and risk of Parkinson’s disease: a systematic r

→ Recent evidence suggests that oxidative stress pla

CRD42022343482 Intakes or circulating levels of vitamin C, vitamin E, and beta-carotene and the

→ Type 2 diabetes (T2D), insulin secretion/deficienc

CRD42015022123 Vitamin C for treating atrial fibrillation [Cochrane Protocol]

→ The Cochrane Heart Group

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables