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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin d

Open on HERB 2.0 ↗

Clinical Trials

837

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin d

Vitamin d Deficiency 6 COVID-19. 6 COVID-19 5 Polycystic Ovary Syndrome 4 The Cochrane Metabolic and Endocrine Disorders Group 4 The Cochrane Airways Group 3 People with different diseases 2 Systemic lupus erythematosus is a systemic autoimmune diseas 2 Gestational diabetes mellitus. 2 COVID-19 is a disease affecting the respiratory system that 2 Tuberculosis 2 The Cochrane Neonatal Group 2

📋 Sample Trials

NCT05357859

Vitamin D for Cognition in Bipolar Disorder

Completed

NCT05656742

Effects of Vitamin D on Cardiovascular Health in Black Women

Recruiting

NCT05459298

ViDES Trial (Vitamin D Extra Supplementation)

Recruiting

📊 Sample Meta-Analyses

CRD42021224844

Vitamin D and type 1 diabetes risk: A systematic review and meta-analysis of genetic evidence to help establish a causal association

Type 1 diabetes mellitus (T1DM) is chronic autoimmune disease posing significant

CRD42014010488

Effects of different doses of Vitamin D replacement in Middle Eastern and North African population: a systematic review and meta-analysis

Hypovitaminosis D is a worldwide problem (Hilger 2014). Low 25-hydroxyvitamin D

CRD42014013380

Effect of vitamin D supplementation on blood pressure and other markers of vascular health: a systematic review and meta-analysis of randomised controlled trials.

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Vitamin d

⚗️ Identity

Name

Vitamin d

Aliases / Synonyms

24,25-Dihydroxyvitamin D; (3R,6R)-6-[(1R,3aS,7aR)-4-[2-[(5S)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol; (6R)-6-[(1R,3aS,4E,7aR)-4-[(2Z)-2-[(5R)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol; 24,25-dihydroxyvitamin D3; 24,25-Dihydroxycholecalciferol; 24,25-dihydroxyvitamin; CHEBI:89324; Q27161510; (3b,5Z,7E)-9,10-Sec...

🧪 Chemistry

Molecular Weight

416.6460

LogP

5.7047

Drug-likeness

0.52

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C

Isomeric SMILES

C[C@H](CCC(C(C)(C)O)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@@H](CCC3=C)O)C

InChIKey

FCKJYANJHNLEEP-OIMXRAFZSA-N

InChI

InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22-,23-,24+,25?,27-/m1/s1

🔗 External References

HERB DB

HBIN048048 ↗

PubChem CID

12895043 ↗

DrugBank

DB11094 ↗

NPASS

NPC270931

SymMap

18308

TCMID

23131

🔍 Raw view — every non-empty column on this row (30 fields)

name

Vitamin d

common names

herb ingredient id

HBIN048048

canonical smiles

CC(CCC(C(C)(C)O)O)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C

isomeric smiles

C[C@H](CCC(C(C)(C)O)O)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@@H](CCC3=C)O)C

inchi

InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22-,23-,24+,25?,27-/m1/s1

inchikey

FCKJYANJHNLEEP-OIMXRAFZSA-N

mol wt

416.6460

num h acceptors

num h donors

mol logp

5.7047

num rotatable bonds

drug likeness

0.52

symmap mol id

18308

tcmid ingredient id

23131

pubchem cid

12895043

drugbank id

DB11094

npass id

NPC270931

🏥 Linked Health Topics

6 · studied for these conditions (text bridge)

Schizophrenia Spectrum And Other Psychotic Disorders

group

Meibomian Gland Dysfunction

syndrome

📋 Clinical Trials

12 · subject of clinical study

NCT05357859 Vitamin D for Cognition in Bipolar Disorder

→ Bipolar Disorder

NCT05656742 Effects of Vitamin D on Cardiovascular Health in Black Women

→ Vitamin d Deficiency

NCT05459298 ViDES Trial (Vitamin D Extra Supplementation)

→ Vitamin D Deficiency

NCT05447065 Impact of Vitamin D Supplementation on COVID-19 Vaccine Response and IgG Antibod

→ COVID-19 Pandemic|D Vitamin Deficiency|Antibody Hy

NCT05449522 Vitamin D for Critically Traumatic Patients

→ Vitamin D Deficiency|Major Trauma

NCT05523986 Vitamin D Treatment Effect for Atopic Dermatitis in Children

→ Atopic Dermatitis

NCT05425914 Impact of Vitamin D3 Supplementation in Non-Sjogren Dry Eye Patients With Low Se

→ Dry Eye Syndromes|Hypovitaminosis D

NCT05387876 Vitamin D Intervention and Associated Changes in the Gut Microbiome and Vitamin

→ Colorectal Cancer

NCT05449145 The Effects of Vitamin D Plus Omega-3 Polyunsaturated Fatty Acids in Patients Wi

→ Episodic Migraine

NCT05595044 Effect of Vitamin D Therapy in Autism Spectrum Disorder

→ Effect of Drug

NCT05497596 The Association Between Human Microbiome and Vitamin D in Chronic Urticaria

→ Urticaria

NCT05211635 Plan D- Vitamin D Supplementation in Psychotic Disorders

→ Schizophrenia Spectrum and Other Psychotic Disorde

📊 Meta-Analyses

12 · systematic review

CRD42021224844 Vitamin D and type 1 diabetes risk: A systematic review and meta-analysis of gen

→ Type 1 diabetes mellitus (T1DM) is chronic autoimm

CRD42014010488 Effects of different doses of Vitamin D replacement in Middle Eastern and North

→ Hypovitaminosis D is a worldwide problem (Hilger 2

CRD42014013380 Effect of vitamin D supplementation on blood pressure and other markers of vascu

CRD42015023473 A meta-analysis of the relationship between vitamin D supplement and hypertensio

→ High blood pressure means SBP over 140mmHg or DBP

CRD42015025346 Effect of vitamin D supplementation on markers of cardiovascular health

→ Cardiovascular disease (blood pressure, inflammato

CRD42015025389 Efficacy of calcium and vitamin D supplementation on the prevention of preeclamp

→ •

CRD42015025679 Vitamin D supplementation for chronic liver diseases in adults [Cochrane Protoco

→ The Cochrane Hepato-Biliary Group

CRD42013006464 The association between vitamin D and renal transplant outcomes: a systematic re

→ Chronic kidney disease (CKD) is highly prevalent,

CRD42012002816 Individual patient meta-analysis of the effect of vitamin D supplementation on b

→ Blood pressure Other markers of vascular function

CRD42018081981 Vitamin D prophylaxis during short course steroid therapy for osteoprotection in

→ Nephrotic syndrome (NS) is one of the common renal

CRD42017083044 Calcium and vitamin D for increasing bone mineral density in premenopausal women

→ The Cochrane Musculoskeletal Group

CRD42015028091 Vitamin D supplementation for obese adults undergoing bariatric surgery [Cochran

→ The Cochrane Metabolic and Endocrine Disorders Gro

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables