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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin d3

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin d3

Asthma, a common chronic inflammatory disorder, is character 1 Bipolar Disorder 1 Although associations of vitamin D deficiency and insufficie 1 Anterior Cruciate Ligament Injuries|Quadriceps Muscle Atroph 1 Vitamin D is currently screened and widely prescribed in app 1 Vitamin D3|Advanced Cancer|Pain Cancer 1 Vitamin D deficiency is a common condition in ICU admission 1 Vitamin D3 Deficiency 1 Treatment of patients with dental malocclusion . Malocclusio 1 Vitamin D|Gestational Diabetes 1 Traditional pairwise meta-analyses indicated that vitamin D 1 Vitamin D Deficiency|Vitiligo 1

📋 Sample Trials

NCT05326841

Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Life of Systemic Lupus Erythematosus Patients .

Completed · Phase 3

NCT05364567

Synergistic Effect of Vitamin D Supplementation in Patients With Vitiligo and Vitamin D Deficiency

Completed

NCT05357859

Vitamin D for Cognition in Bipolar Disorder

Completed

📊 Sample Meta-Analyses

CRD42015020157

Is combined resistance exercise training and vitamin D3 supplementation more effective than resistance exercise alone? A systematic review investigating the effects on muscle and bone function in older adults

The human ageing process is typified by concomitant losses in muscle and bone ma

CRD42020185566

Efficacy of Vitamin D3 supplementation on cancer mortality in the general population and the prognosis of cancer patients: a systematic review and individual patient data meta-analysis of randomized controlled trials

Cancer

CRD42016045231

Vitamin D3 supplementation and asthma control: a meta-analysis of randomized controlled trials

Asthma, a common chronic inflammatory disorder, is characterized clinically by r

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for Vitamin d3

⚗️ Identity

Name

Vitamin d3

Aliases / Synonyms

cholecalciferol; 67-97-0; Colecalciferol; Calciol; Ricketon; Oleovitamin D3; Deparal; Arachitol; Delsterol

🧪 Chemistry

Molecular Weight

384.6480

LogP

7.6190

Drug-likeness

0.499

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C

Isomeric SMILES

C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C

InChIKey

QYSXJUFSXHHAJI-YRZJJWOYSA-N

InChI

InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

🔗 External References

HERB DB

HBIN048050 ↗

PubChem CID

5280795 ↗

DrugBank

DB00169 ↗

TCMID

23198

🔍 Raw view — every non-empty column on this row (28 fields)

name

Vitamin d3

common names

cholecalciferol; 67-97-0; Colecalciferol; Calciol; Ricketon; Oleovitamin D3; Deparal; Arachitol; Delsterol

herb ingredient id

HBIN048050

canonical smiles

CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C

isomeric smiles

C[C@H](CCCC(C)C)[C@H]1CC[C@@H]\2[C@@]1(CCC/C2=C\C=C/3\C[C@H](CCC3=C)O)C

inchi

InChI=1S/C27H44O/c1-19(2)8-6-9-21(4)25-15-16-26-22(10-7-17-27(25,26)5)12-13-23-18-24(28)14-11-20(23)3/h12-13,19,21,24-26,28H,3,6-11,14-18H2,1-2,4-5H3/b22-12+,23-13-/t21-,24+,25-,26+,27-/m1/s1

inchikey

QYSXJUFSXHHAJI-YRZJJWOYSA-N

mol wt

384.6480

num h acceptors

num h donors

mol logp

7.6190

num rotatable bonds

drug likeness

0.499

tcmid ingredient id

23198

pubchem cid

5280795

drugbank id

DB00169

🏥 Linked Health Topics

2 · studied for these conditions (text bridge)

📋 Clinical Trials

11 · subject of clinical study

NCT05326841 Effect of Cholecalciferol Supplementation on Disease Activity and Quality of Lif

→ Lupus Erythematosus, Systemic|Cholecalciferol Supp

NCT05364567 Synergistic Effect of Vitamin D Supplementation in Patients With Vitiligo and Vi

→ Vitamin D Deficiency|Vitiligo

NCT05357859 Vitamin D for Cognition in Bipolar Disorder

→ Bipolar Disorder

NCT05356936 Pilot Study of Vitamin K2 (MK-7) and Vitamin D3 Supplementation and the Effects

→ Post-acute COVID-19 Syndrome

NCT05244018 Outcome of High Dose Vitamin D on Prognosis of Sepsis Requiring Mechanical Venti

→ Sepsis

NCT05450419 The Role of Vitamin D3 Supplementation in Advanced Cancer Patients With Pain

→ Vitamin D3|Advanced Cancer|Pain Cancer

NCT05657678 Vitamin D3 Supplementation in Critically Ill Patients Undergoing CRRT

→ Vitamin D3 Deficiency

NCT05209425 Pharmacokinetics Evaluation of Vitamin D Formulations

→ Vitamin D

NCT05306704 High-Dose Vitamin D3 Supplementation in the Treatment of Human Immune Deficiency

→ HIV-1-infection|Hypovitaminosis D

NCT05208827 Vitamin D Supplementation for the Prevention of GDM

→ Vitamin D|Gestational Diabetes

NCT05174611 Vitamin D to Improve Quadricep Muscle Strength

→ Anterior Cruciate Ligament Injuries|Quadriceps Mus

📊 Meta-Analyses

11 · systematic review

CRD42015020157 Is combined resistance exercise training and vitamin D3 supplementation more eff

→ The human ageing process is typified by concomitan

CRD42020185566 Efficacy of Vitamin D3 supplementation on cancer mortality in the general popula

→ Cancer

CRD42016045231 Vitamin D3 supplementation and asthma control: a meta-analysis of randomized con

→ Asthma, a common chronic inflammatory disorder, is

CRD42017060103 Effect of daily vitamin D3 supplementation on human health and performance: prot

→ The study will accept any outcome measure related

CRD42019136146 Efficacy of vitamin D3 buccal spray compared to all other delivery methods in im

→ The condition studied involves serum 25(OH)D level

CRD42020179195 High-dose of Vitamin D3 is not associated with lower mortality of ICU patients:

→ Vitamin D deficiency is a common condition in ICU

CRD42021209928 The effect of local administration of vitamin D3 on canine distalisation: a syst

→ Treatment of patients with dental malocclusion . M

CRD42021253201 Protocol for an umbrella review of systematic reviews of health-related outcomes

→ Vitamin D is currently screened and widely prescri

CRD42021259162 Vitamin D3 supplementation prior to in vitro fertilization and embryo transfer:

→ Supplementation with vitamin D3 in couple undergoi

CRD42022309640 The effect of Vitamin D3 supplementation on depression: a protocol for a systema

→ Traditional pairwise meta-analyses indicated that

CRD42023441928 Updated systematic review on vitamin D supplementation, mortality and cardiovasc

→ Although associations of vitamin D deficiency and

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables