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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Taxol Oxytocin Morphine (?)-nicotine Testosterone Melatonin Caffeine L-ascorbic acid Progesterone Coumarins

⚗️ Ingredient

Vitamin k1

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin k1

End Stage Renal Disease on Dialysis 1 Coagulation 1 In patients with end stage kidney disease, cardiovascular di 1 Vascular Calcification 1 Hepatocellular Carcinoma 1 Glioblastoma|Glioblastoma Multiforme 1

📋 Sample Trials

NCT04477811

Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients

Completed · Phase 2|Phase 3

NCT04752813

A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastoma (GB)

Recruiting · Phase 2

NCT00794755

Low Dose Supplementation to Improve Anticoagulation Control With Oral Vitamin K as an Adjuvant to Warfarin Therapy

Completed · Phase 3

📊 Sample Meta-Analyses

CRD42020123104

Vitamin K1 to prevent the progression of arterial calcification in patients with end stage kidney disease: a meta-analysis of randomized controlled trials

In patients with end stage kidney disease, cardiovascular disease accounts for m

📚 Sample References

PMID 34444740

Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-Bleeding Critically Ill Patients: A Prospective Observational Study

Nutrients · 2021

⚗️ All Ingredient data fields for Vitamin k1

⚗️ Identity

Name

Vitamin k1

Aliases / Synonyms

Phylloquinone; phytonadione; 84-80-0; Phytomenadione; Phytylmenadione; 3-Phytylmenadione; Aquamephyton; Phyllochinon; Konakion

🧪 Chemistry

Molecular Weight

450.7070

LogP

9.1576

Drug-likeness

0.265

H-Bond Acceptors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C

Isomeric SMILES

CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C

InChIKey

MBWXNTAXLNYFJB-NKFFZRIASA-N

InChI

InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

🔗 External References

HERB DB

HBIN048068 ↗

PubChem CID

5284607 ↗

DrugBank

DB01022 ↗

NPASS

NPC106653

TCMID

22546

TCM-ID

24264

🔍 Raw view — every non-empty column on this row (30 fields)

name

Vitamin k1

common names

Phylloquinone; phytonadione; 84-80-0; Phytomenadione; Phytylmenadione; 3-Phytylmenadione; Aquamephyton; Phyllochinon; Konakion

herb ingredient id

HBIN048068

canonical smiles

CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCCC(C)CCCC(C)CCCC(C)C

isomeric smiles

CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C

inchi

InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1

inchikey

MBWXNTAXLNYFJB-NKFFZRIASA-N

mol wt

450.7070

num h acceptors

num h donors

mol logp

9.1576

num rotatable bonds

drug likeness

0.265

tcmid ingredient id

22546

tcm id ingredient id

24264

pubchem cid

5284607

drugbank id

DB01022

npass id

NPC106653

🏥 Linked Health Topics

2 · diseases via target pathways

Vascular Calcification

phenotype

Hepatocellular carcinoma

disease

📋 Clinical Trials

5 · subject of clinical study

NCT04477811 Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascu

→ End Stage Renal Disease on Dialysis

NCT04752813 A Study of BPM31510 With Vitamin K1 in Subjects With Newly Diagnosed Glioblastom

→ Glioblastoma|Glioblastoma Multiforme

NCT00794755 Low Dose Supplementation to Improve Anticoagulation Control With Oral Vitamin K

→ Coagulation

NCT02259647 Sorafenib Plus Vitamin K1 Versus Sorafenib in Advanced Hepatocellular Carcinoma

→ Hepatocellular Carcinoma

NCT05060809 Vitamin k1 and Its Relation to Vascular Calcification in Hemodialysis Patients

→ Vascular Calcification

📊 Meta-Analyses

1 · systematic review

CRD42020123104 Vitamin K1 to prevent the progression of arterial calcification in patients with

→ In patients with end stage kidney disease, cardiov

📚 PubMed References

1 · cited research

PMID 34444740 Intravenous Vitamin K1 for the Correction of Prolonged Prothrombin Times in Non-

Nutrients

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables