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Disease
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trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Vitamin k2

Open on HERB 2.0 ↗
22
Clinical Trials
3
Meta-Analyses
9
PubMed References
Top Conditions Studied with Vitamin k2
Healthy 3 Vascular Calcification 2 Osteoporosis 1 Arterial Stiffness|Vitamin K2 Deficiency 1 Nocturnal Leg Cramps 1 Aortic Valve Stenosis|Aortic Valve Calcification|Mitral Annu 1 Inflammation|Oxidative Stress|Vitamin K|Exercise|Strength|Re 1 Postmenopausal women with osteoporosis. 1 Postmenopausal osteoporosis. Physical activity in elderly wo 1 Fracture Healing|Vitamin D3|Deficiency of Vitamin K2 1 Vitamin K Supplementation|Endstage Renal Disease|Cardiovascu 1 End Stage Renal Disease on Dialysis 1
📋 Sample Trials
NCT04477811
Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascular Calcification in Dialysis Patients
Completed · Phase 2|Phase 3
NCT00548509
The Effect of Vitamin K2 on Bone Turnover
Completed · Phase 4
NCT00742768
Comparison of Absorption of Vitamin K2
Completed
📊 Sample Meta-Analyses
CRD42017068567
Efficacy and safety of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: a meta-analysis of 19 randomized controlled trials
Postmenopausal osteoporosis. Physical activity in elderly women.
CRD42017070250
The efficacy and safety of vitamin K2 in the prevention and treatment of postmenopausal osteoporosis: a meta-analysis of nineteen randomized controlled trials
Postmenopausal women with osteoporosis.
CRD42023465053
Vitamin K2 Promotes Bone injury Repair in Osteoporosis: A Systematic Literature Review
📚 Sample References
PMID 26466318
Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperplasia and calcification in arterialized veins: role of vitamin K treatment?
Kidney Int · 2016
PMID 22169620
Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemodialysis patients: a randomized trial
Am J Kidney Dis · 2012
PMID 32253917
Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitochondrial Function Via SIRT1 Signaling
Antioxid Redox Signal · 2021
⚗️ All Ingredient data fields for Vitamin k2
⚗️ Identity
Name
Vitamin k2
Aliases / Synonyms
cis-Vitamin K2; SCHEMBL8703544; (Z,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; cis-Vitamin K2(20); 65061-19-0
🧪 Chemistry
Molecular Weight
444.6590
LogP
8.9179
Drug-likeness
0.319
H-Bond Acceptors
2
Rotatable Bonds
11
🔬 Structures
Canonical SMILES
CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
Isomeric SMILES
CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(/C)\CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C
InChIKey
DKHGMERMDICWDU-IFQAVNAMSA-N
InChI
InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20-
🔗 External References
HERB DB
HBIN048069 ↗
PubChem CID
13728967 ↗
DrugBank
DB14936 ↗
NPASS
NPC68016
TCMID
22547
TCM-ID
14701
🔍 Raw view — every non-empty column on this row (30 fields)
name
Vitamin k2
common names
cis-Vitamin K2; SCHEMBL8703544; (Z,E,E)-2-Methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthalenedione; cis-Vitamin K2(20); 65061-19-0
herb ingredient id
HBIN048069
canonical smiles
CC1=C(C(=O)C2=CC=CC=C2C1=O)CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C
isomeric smiles
CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(/C)\CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C
inchi
InChI=1S/C31H40O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,12,14,16,18-20H,9-11,13,15,17,21H2,1-6H3/b23-14+,24-16+,25-20-
inchikey
DKHGMERMDICWDU-IFQAVNAMSA-N
mol wt
444.6590
num h acceptors
2
num h donors
0
mol logp
8.9179
num rotatable bonds
11
drug likeness
0.319
tcmid ingredient id
22547
tcm id ingredient id
14701
pubchem cid
13728967
drugbank id
DB14936
npass id
NPC68016

🏥 Linked Health Topics

4 · diseases via target pathways
Osteoporosis
syndrome
Thrombosis
phenotype
Vascular Calcification
phenotype
Chronic Kidney Diseases
group

📋 Clinical Trials

12 · subject of clinical study
NCT04477811 Comparative Study Evaluating the Effect of Vitamin K1 Versus Vitamin K2 on Vascu
→ End Stage Renal Disease on Dialysis
NCT00548509 The Effect of Vitamin K2 on Bone Turnover
→ Osteoporosis
NCT00742768 Comparison of Absorption of Vitamin K2
→ Healthy
NCT01194778 Comparison of Efficacy of Different Dosages Vitamin K2
→ Carboxylation Level|Vitamin K-dependent Proteins
NCT01533441 Vitamin K2 Intervention in Patients With Vitamin K Antagonists
→ Thrombosis
NCT01675206 Dose Defining Study for the Administration of Vitamin K2 Supplements in Hemodial
→ Vascular Calcification
NCT02517580 Vitamin K2 Supplementation and Arterial Stiffness in the Renal Transplant Popula
→ Arterial Stiffness|Vitamin K2 Deficiency
NCT02970084 Vitamin K2 for Reduction the Calcium at Carotid Bifurcation in Patients With Sub
→ Carotid Plaques
NCT02976246 Effect of Vitamin K2 (MK7) on Cardiovascular and Bone Disease in Dialysis Patien
→ Vitamin K Supplementation|Endstage Renal Disease|C
NCT04429035 SLOW-Slower Progress of caLcificatiOn With Vitamin K2
→ Aortic Valve Stenosis|Aortic Valve Calcification|M
NCT04770740 Randomized Controlled Clinical Trial to Investigate Effects of Vitamin K2 in COV
→ Covid19
NCT02610933 Effect on Vascular Calcification of Replacing Warfarin by Rivaroxaban With or Wi
→ Vascular Calcification

📊 Meta-Analyses

3 · systematic review
CRD42017068567 Efficacy and safety of vitamin K2 in the prevention and treatment of postmenopau
→ Postmenopausal osteoporosis. Physical activity in
CRD42017070250 The efficacy and safety of vitamin K2 in the prevention and treatment of postmen
→ Postmenopausal women with osteoporosis.
CRD42023465053 Vitamin K2 Promotes Bone injury Repair in Osteoporosis: A Systematic Literature

📚 PubMed References

9 · cited research
PMID 26466318 Vitamin K antagonism aggravates chronic kidney disease-induced neointimal hyperp
Kidney Int
PMID 22169620 Effect of vitamin K2 supplementation on functional vitamin K deficiency in hemod
Am J Kidney Dis
PMID 32253917 Vitamin K2 Alleviates Insulin Resistance in Skeletal Muscle by Improving Mitocho
Antioxid Redox Signal
PMID 32848799 Vitamin K2 Can Rescue the Dexamethasone-Induced Downregulation of Osteoblast Aut
Front Pharmacol
PMID 34202933 Vitamin K2 Modulates Organelle Damage and Tauopathy Induced by Streptozotocin an
Antioxidants (Basel)
PMID 35326164 Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterio
Antioxidants (Basel)
PMID 35406117 Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in S
Nutrients
PMID 35889891 Vitamin K2 Improves Osteogenic Differentiation by Inhibiting STAT1 via the Bcl-6
Nutrients
PMID 36358523 Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/
Antioxidants (Basel)
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables