Relationship Graph Explorer

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Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.

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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

Quick picks: Fufang Danshen Dripping Pills; Comp Dajian Zhong Decoction; Da Jian Zho Shen Fu Injection Danggui Buxue Decoction; Dang Gui B Xiao Chai Hu Decoction Huangqi Guizhi Wuwu Decoction; Huan Xue Fu Zhu Yu Capsule; Xuefu Zhuyu Tian Wang Bu Xin Dan Ren Shen Yang Rong Decoction An Gong Niu Huang Pill; Angong Niuh

📜 Formula

Si Ni Powder

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Si Ni Powder

Insomnia 1 Irritable Bowel Syndrome 1

📋 Sample Trials

NCT02653937

The Effect of Shigyakusan Used for IBS and MUPS Diagnosed by Abdominal N Line Tenderness

Completed

📊 Sample Meta-Analyses

CRD42022346435

Meta-analysis of the efficacy and safety of Sini Powder and its combined therapy in the treatment of insomnia

Insomnia

📚 Sample References

PMID 16557606

Preventive effect of Shigyaku-san on progression of acute gastric mucosal lesions induced by compound 48/80, a mast cell degranulator, in rats

Phytother Res · 2006

PMID 19211027

Dissection of the role of paeoniflorin in the traditional Chinese medicinal formula Si-Ni-San against contact dermatitis in mice

Life Sci · 2009

PMID 32009949

Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and Regulating CYP450 Enzymatic Activity

Front Pharmacol · 2020

📜 All Formula data fields for Si Ni Powder

📜 Names

Pinyin Name

Si Ni San

中文名 (Chinese)

四逆散

English Name

Si Ni Powder

💊 Form & Use

Type (类别)

理气药

🌿 Related Herbs

3 · contains this compound

White Peony Root

Bai Shao

Chinese Thorowax Root; Root of Chinese Thorowax

Chai Hu

Liquorice Root; Root of Ural Licorice

Gan Cao

📋 Clinical Trials

1 · subject of clinical study

NCT02653937 The Effect of Shigyakusan Used for IBS and MUPS Diagnosed by Abdominal N Line Te

→ Irritable Bowel Syndrome

📊 Meta-Analyses

1 · systematic review

CRD42022346435 Meta-analysis of the efficacy and safety of Sini Powder and its combined therapy

→ Insomnia

📚 PubMed References

9 · cited research

PMID 16557606 Preventive effect of Shigyaku-san on progression of acute gastric mucosal lesion

Phytother Res

PMID 19211027 Dissection of the role of paeoniflorin in the traditional Chinese medicinal form

Life Sci

PMID 32009949 Si-Ni-San Prevents Reserpine-Induced Depression by Inhibiting Inflammation and R

Front Pharmacol

PMID 33611210 Si-Ni-San ameliorates chronic colitis by modulating type I interferons-mediated

Phytomedicine

PMID 34276360 Network Pharmacological Analysis and Experimental Validation of the Mechanisms o

Front Pharmacol

PMID 34912211 Sini San Inhibits Chronic Psychological Stress-Induced Breast Cancer Stemness by

Front Pharmacol

PMID 36003517 Ameliorative effect and mechanism of Si-Ni-San on chronic stress-induced diarrhe

Front Pharmacol

PMID 36334816 Si-Ni-SAN ameliorates obesity through AKT/AMPK/HSL pathway-mediated lipolysis: N

J Ethnopharmacol

PMID 36460296 Sini San ameliorates CCl4-induced liver fibrosis in mice by inhibiting AKT-media

J Ethnopharmacol

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
Target ↔ Disease: ACTIVE — direct link via target_health_topics
Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables