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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Vitamin e

Open on HERB 2.0 ↗

131

Clinical Trials

110

Meta-Analyses

PubMed References

Top Conditions Studied with Vitamin e

Prostate Cancer 3 Sepsis 3 Septic Shock 2 Cardiovascular Diseases 2 NAFLD 2 Asthma 2 Thiamine Deficiency 2 Chronic Arsenic Poisoning 2 Breast Cancer 2 Alzheimer Disease 2 Neoplasms 1 Drug Toxicity|Lung Cancer 1

📋 Sample Trials

NCT00003367

Diet and PSA Levels in Patients With Prostate Cancer

Completed · Phase 3

NCT03258684

Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock

Completed

NCT03333278

The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42020170648

Effect of combined vitamin C, hydrocortisone and thiamine for patients with septic shock: a systematic review and meta-analysis

Nowadays, the mortality rate of septic shock remains as high as 50%, so the new

CRD42020203166

Hydrocortisone, ascorbic acid and thiamine for sepsis and septic shock: a meta-analysis

The effect of treatment with hydrocortisone, ascorbic acid, and thiamine for sep

CRD42020206950

Combination therapy of thiamine and vitamin C in treating patients with sepsis or septic shock: A systematic review and meta-analysis

Sepsis is a common yet complex disorder that remains one of the major causes of

📚 Sample References

PMID 31607237

Vitamin E attenuates alterations in learning, memory and BDNF levels caused by perinatal ethanol exposure

Nutr Neurosci · 2021

PMID 33216086

Dietary vitamin E regulates the activity of antioxidant enzymes through Wnt10b signaling in the muscle of zebrafish

Food Funct · 2020

PMID 33617844

Vitamin E pretreated Wharton's jelly-derived mesenchymal stem cells attenuate CCl4-induced hepatocyte injury in vitro and liver fibrosis in vivo

Biochem Pharmacol · 2021

⚗️ All Ingredient data fields for Vitamin e

⚗️ Identity

Name

Vitamin e

Aliases / Synonyms

alpha-Tocopherol; 59-02-9; D-alpha-Tocopherol; 5,7,8-Trimethyltocol; (+)-alpha-Tocopherol; 2074-53-5; alpha Tocopherol; Phytogermine; TOCOPHEROL

🧪 Chemistry

Molecular Weight

430.7170

LogP

8.8403

Drug-likeness

0.359

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C

Isomeric SMILES

CC1=C(C2=C(CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=C1O)C)C

InChIKey

GVJHHUAWPYXKBD-IEOSBIPESA-N

InChI

InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC242580

HIT

C0482

TCMID

21399; 32686; 32685; 32214; 39298

TCMSP

MOL002771; MOL005056

TCM-ID

17605

🔍 Raw view — every non-empty column on this row (33 fields)

name

Vitamin e

common names

alpha-Tocopherol; 59-02-9; D-alpha-Tocopherol; 5,7,8-Trimethyltocol; (+)-alpha-Tocopherol; 2074-53-5; alpha Tocopherol; Phytogermine; TOCOPHEROL

herb ingredient id

HBIN048145

canonical smiles

CC1=C(C2=C(CCC(O2)(C)CCCC(C)CCCC(C)CCCC(C)C)C(=C1O)C)C

isomeric smiles

CC1=C(C2=C(CC[C@@](O2)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)C(=C1O)C)C

inchi

InChI=1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1

inchikey

GVJHHUAWPYXKBD-IEOSBIPESA-N

mol wt

430.7170

num h acceptors

num h donors

mol logp

8.8403

num rotatable bonds

drug likeness

0.359

cas id

1406-18-4

tcmid ingredient id

21399; 32686; 32685; 32214; 39298

tcmsp ingredient id

MOL002771; MOL005056

tcm id ingredient id

17605

pubchem cid

14985

drugbank id

DB00163; DB11251

npass id

NPC242580

hit id

C0482

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Amyotrophic Lateral Sclerosis

Cardiovascular Diseases

group

Primary Biliary Cirrhosis

📋 Clinical Trials

12 · subject of clinical study

NCT00003367 Diet and PSA Levels in Patients With Prostate Cancer

→ Prostate Cancer

NCT03258684 Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic S

→ Sepsis

NCT03333278 The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial

→ Shock, Septic|Critically Ill|Vasoplegic Syndrome|S

NCT03872011 Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock

→ Septic Shock

NCT04160676 Therapy With Hydrocortisone, Ascorbic Acid, Thamine in Patients With Sepsis

→ Sepsis

NCT00169845 Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancie

→ Neoplasms

NCT01934777 Efficacy and Tolerance of Treatment With DHA, Choline and Vitamin E in Children

→ Fatty Liver|Liver Fibrosis|Obesity|Metabolic Syndr

NCT01125033 Study of Vitamin C, Vitamin E and Their Combination to Treat Restless Legs Syndr

→ Restless Legs Syndrome|Kidney Failure, Chronic

NCT01743742 First-day High Dose Vitamin C, E in Severe Birth Asphyxia

→ Birth Asphyxia

NCT02793648 Effectiveness of Ascorbic Acid and Tocopherol for Depression in Elderly.

→ Depression

NCT03422159 Metabolic Resuscitation Using Ascorbic Acid, Thiamine, and Glucocorticoids in Se

→ Sepsis, Severe|Septic Shock

NCT03509350 Vitamin C, Thiamine, and Steroids in Sepsis

→ Sepsis

📊 Meta-Analyses

12 · systematic review

CRD42020170648 Effect of combined vitamin C, hydrocortisone and thiamine for patients with sept

→ Nowadays, the mortality rate of septic shock remai

CRD42020203166 Hydrocortisone, ascorbic acid and thiamine for sepsis and septic shock: a meta-a

→ The effect of treatment with hydrocortisone, ascor

CRD42020206950 Combination therapy of thiamine and vitamin C in treating patients with sepsis o

→ Sepsis is a common yet complex disorder that remai

CRD42020207832 Combined treatment with ascorbic acid, hydrocortisone, and thiamine for patients

→ Sepsis rapidly progresses causing multiple organ d

CRD42020209086 Efficacy of Vitamin C, Thiamine, Steroids for Treatment in Sepsis Patients: A Sy

→ Sepsis or septic shock: Sepsis is an inflammatory

CRD42020216665 Benefit of hydrocortisone, thiamine, and vitamin C for patients with sepsis or s

→ Sepsis/ septic shock requiring vasopressor/ inotro

CRD42020220036 The Effectiveness of One or Combination of Vitamin C or Thiamine or Hydrocortiso

→ Description of The Condition Sepsis, if unable to

CRD42020220135 Thiamine, ascorbic acid and hydrocortisone as metabolic resuscitation cocktail i

→ Septic shock, Sepsis, metabolic resuscitation

CRD42019118808 Parenteral thiamine for the prevention and treatment of delirium in critically i

→ Delirium is an acute confusional state that is com

CRD42022318388 Vitamin C, Vitamin E, β-carotene and risk of Parkinson’s disease: a systematic r

→ Recent evidence suggests that oxidative stress pla

CRD42022343482 Intakes or circulating levels of vitamin C, vitamin E, and beta-carotene and the

→ Type 2 diabetes (T2D), insulin secretion/deficienc

CRD42021250425 The effect of N-acetyl cysteine and vitamin E on oxidative status and blood para

→ The oxidative status and blood parameters

📚 PubMed References

9 · cited research

PMID 31607237 Vitamin E attenuates alterations in learning, memory and BDNF levels caused by p

Nutr Neurosci

PMID 33216086 Dietary vitamin E regulates the activity of antioxidant enzymes through Wnt10b s

Food Funct

PMID 33617844 Vitamin E pretreated Wharton's jelly-derived mesenchymal stem cells attenuate CC

Biochem Pharmacol

PMID 34089243 Administration of vitamin E attenuates airway inflammation through restoration o

J Cell Mol Med

PMID 34710615 Different forms of vitamin E and metabolite 13'-carboxychromanols inhibit cycloo

J Nutr Biochem

PMID 35112986 Effect of α-tocopherol in alleviating the lipopolysaccharide-induced acute lung

Bioengineered

PMID 35227771 Vitamin E rescues valproic acid-induced testicular injury in rats: Role of autop

Life Sci

PMID 36290792 Effects of Dietary Vitamin E Supplementation on Reproductive Performance, Egg Ch

Antioxidants (Basel)

PMID 36613525 Hepato-Protective Effects of Delta-Tocotrienol and Alpha-Tocopherol in Patients

Int J Mol Sci

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables