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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Xylitol

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Xylitol

Dental Caries 5 Cystic Fibrosis 2 Obesity 2 End Stage Renal Disease 1 Allogeneic Hematopoietic Cell Transplantation 1 Dental caries is an infectious disease which is a problem al 1 Dental Caries|Periodontal Diseases 1 Acute Otitis Media 1 Dental caries in humans. 1 Dental Caries|Infectious Diseases 1 Caries has a complex etiology of a multifactorial nature and 1 Dental Caries and Streptococcus Mutans Count 1

📋 Sample Trials

NCT03668015

Xylitol and Sorbitol Effects on the Oral Microbiome

Completed

NCT00638677

Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Pacifier

Completed · Phase 4

NCT00924404

Xylitol Versus Saline in Chronic Sinusitis

Completed

📊 Sample Meta-Analyses

CRD42022348877

The effect of xylitol on P. Gingivalis: A Systematic Review

Periodontal Disease

CRD42022376771

Impact of the baseline caries level on the effect of xylitol chewing gum and confectionery on caries occurrence in children: a systematic review

Dental caries is an infectious disease which is a problem all over the world. Ca

CRD42015025983

Xylitol use during pregnancy and lactation to prevent early childhood caries

Early childhood caries (ECC) is a particularly virulent form of dental caries th

📚 Sample References

PMID 30150693

Ribitol restores functionally glycosylated α-dystroglycan and improves muscle function in dystrophic FKRP-mutant mice

Nat Commun · 2018

PMID 35631164

Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Cell Proliferation and Glycolysis of Mice Bearing Orthotopic Xenograft of Oral Cancer

Nutrients · 2022

⚗️ All Ingredient data fields for Xylitol

⚗️ Identity

Name

Xylitol

Aliases / Synonyms

ribitol; adonitol; 488-81-3; 87-99-0; Xylite; D-Xylitol; Adonite; Adonit; Xyliton

🧪 Chemistry

Molecular Weight

152.1460

LogP

-2.9463

Drug-likeness

0.296

Oral Bioavailability

27.3710

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C(C(C(C(CO)O)O)O)O

Isomeric SMILES

C([C@H](C([C@H](CO)O)O)O)O

InChIKey

HEBKCHPVOIAQTA-NGQZWQHPSA-N

InChI

InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5?

🔗 External References

HERB DB

PubChem CID

CAS Number

DrugBank

NPASS

NPC187058

SymMap

6577

TCMID

22798

TCMSP

MOL004712; MOL009301

🔍 Raw view — every non-empty column on this row (33 fields)

name

Xylitol

common names

ribitol; adonitol; 488-81-3; 87-99-0; Xylite; D-Xylitol; Adonite; Adonit; Xyliton

herb ingredient id

HBIN048522

canonical smiles

C(C(C(C(CO)O)O)O)O

isomeric smiles

C([C@H](C([C@H](CO)O)O)O)O

inchi

InChI=1S/C5H12O5/c6-1-3(8)5(10)4(9)2-7/h3-10H,1-2H2/t3-,4+,5?

inchikey

HEBKCHPVOIAQTA-NGQZWQHPSA-N

mol wt

152.1460

num h acceptors

num h donors

mol logp

-2.9463

num rotatable bonds

drug likeness

0.296

ob score

27.3710

cas id

87-99-0

symmap mol id

6577

tcmid ingredient id

22798

tcmsp ingredient id

MOL004712; MOL009301

pubchem cid

6912

drugbank id

DB11195

npass id

NPC187058

🏥 Linked Health Topics

7 · studied for these conditions (text bridge)

📋 Clinical Trials

12 · subject of clinical study

NCT03668015 Xylitol and Sorbitol Effects on the Oral Microbiome

→ Human Microbiome

NCT00638677 Bifidobacterium Lactis BB12 and Xylitol Delivered With a Novel Slow-release Paci

→ Dental Caries|Infectious Diseases

NCT00924404 Xylitol Versus Saline in Chronic Sinusitis

→ Chronic Sinusitis

NCT00928135 Aerosolized Hypertonic Xylitol Versus Hypertonic Saline in Cystic Fibrosis (CF)

→ Cystic Fibrosis

NCT01044030 Xylitol Syrup for the Prevention of Acute Otitis Media in Otitis-prone Children

→ Acute Otitis Media

NCT01355796 Inhaled Xylitol Versus Saline in Stable Subjects With Cystic Fibrosis

→ Cystic Fibrosis

NCT01528969 Effect of Xylitol on Oral Microbiota in Children

→ Bacterial Infections

NCT01901250 Xylitol for Caries Prevention in Inner-City Children

→ Dental Caries

NCT04001036 Efficacy and Safety Assessments of a Peritoneal Dialysis Solution Containing Glu

→ End Stage Renal Disease

NCT04117477 Xylitol - Healthcare Associated Infection Reduction in Stem Cell Transplant Pati

→ Allogeneic Hematopoietic Cell Transplantation

NCT04399161 Anticaries Effect of Xylitol,Probiotic and Chlorhexidine Mouth Rinses Among Indi

→ Cariostatic Agents|Mouthwashes

NCT00393055 Xylitol Adult Caries Trial (X-ACT)

→ Dental Caries

📊 Meta-Analyses

12 · systematic review

CRD42022348877 The effect of xylitol on P. Gingivalis: A Systematic Review

→ Periodontal Disease

CRD42022376771 Impact of the baseline caries level on the effect of xylitol chewing gum and con

→ Dental caries is an infectious disease which is a

CRD42015025983 Xylitol use during pregnancy and lactation to prevent early childhood caries

→ Early childhood caries (ECC) is a particularly vir

CRD42020150746 A systematic review and meta-analysis to compare caries preventing and remineral

→ The progression or reversal of dental caries depen

CRD42020219021 Effects of xylitol consumption on the amount of plaque: a systematic review

→ Dental plaque is a risk factor of caries. Xylitol

CRD42020141189 Does xylitol reduce the risk of or prevent dental caries?

→ Dental caries in humans.

CRD42020168945 Effect of xylitol-containing products on dental caries: A systematic review and

→ Based on WHO, dental caries is one of the most pre

CRD42020197945 Evaluation the effectiveness of chewing gum containing only xylitol compared to

→ Caries has a complex etiology of a multifactorial

CRD42018117424 Xylitol toothpaste effect on preventing dental caries: a systematic review

→ Dental caries is the most widespread oral disease

CRD42023425286 Xylitol nasal irrigation in the treatment of chronic rhinosinusitis - a systemat

→ Rhinosinusitis is characterized by inflammation of

CRD42023447360 Effect of long-term xylitol intake on dental caries: A Systematic Review and Met

→ dental caries

CRD42023492793 Effect of Xylitol Containing Chewing Gums on Oral Microflora-A Systematic Review

→ This study aims to know the Effect of Xylitol cont

📚 PubMed References

2 · cited research

PMID 30150693 Ribitol restores functionally glycosylated α-dystroglycan and improves muscle fu

Nat Commun

PMID 35631164 Partial Substitution of Glucose with Xylitol Prolongs Survival and Suppresses Ce

Nutrients

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables