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Gene Target
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Disease
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Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
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⚗️ Ingredient

Zeaxanthine

Open on HERB 2.0 ↗
11
Clinical Trials
4
Meta-Analyses
3
PubMed References
Top Conditions Studied with Zeaxanthine
Age Related Maculopathy 2 optimal ocular tissue health 1 Assessment of dietary intake is known to involve a number of 1 Age Related Macular Degeneration|Cognition Disorders 1 Age-related Macular Degeneration (AMD) is the leading cause 1 Ocular Albinism (OA)|Oculocutaneous Albinism (OCA) 1 Macular Degeneration 1 Exudative Age-related Macular Degeneration 1 Epiretinal Membrane|Macular Hole|Proliferative Diabetic Reti 1 Cataract 1 Behavior and Behavior Mechanisms 1 Age-related Macular Degeneration|Cataract 1
📋 Sample Trials
NCT00121589
Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60
Completed · Phase 1
NCT01528605
Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular Degeneration
Completed
NCT01621789
Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsule
Completed · Phase 3
📊 Sample Meta-Analyses
CRD42016045942
Lutein and zeaxanthin for reducing morbidity and mortality in preterm infants [Cochrane Protocol]
The Cochrane Neonatal Group
CRD42020197594
Systematic review of the evidence on lutein/zeaxanthin intake and human macular pigment optical density
optimal ocular tissue health
CRD42023485956
Assessment of biological carotenoid levels as biomarkers of dietary intake: a systematic review and meta-analysis protocol
Assessment of dietary intake is known to involve a number of challenges and limi
📚 Sample References
PMID 33689686
A novel gastroprotective effect of zeaxanthin against stress-induced gastritis in male rats targeting the expression of HIF-1α, TFF-1 and MMP-9 through PI3K/Akt/JNK signaling pathway
Life Sci · 2021
PMID 34047728
Zeaxanthin promotes browning by enhancing mitochondrial biogenesis through the PKA pathway in 3T3-L1 adipocytes
Food Funct · 2021
PMID 36500974
Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced Obese Rats
Nutrients · 2022
⚗️ All Ingredient data fields for Zeaxanthine
⚗️ Identity
Name
Zeaxanthine
Aliases / Synonyms
Zeaxanthin; 144-68-3; Anchovyxanthin; Zeaxanthol; all-trans-Zeaxanthin; Xanthophyll 3; Beta,beta-carotene-3,3'-diol; Luteinofta; Optisharp; Zeagold
🧪 Chemistry
Molecular Weight
568.8860
LogP
10.5474
Drug-likeness
0.257
H-Bond Acceptors
2
H-Bond Donors
2
Rotatable Bonds
10
🔬 Structures
Canonical SMILES
CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CC(CC2(C)C)O)C)C)C
Isomeric SMILES
CC1=C(C(C[C@@H](C1)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C[C@H](CC2(C)C)O)C)\C)\C)/C)/C
InChIKey
JKQXZKUSFCKOGQ-QAYBQHTQSA-N
InChI
InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-24,35-36,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36-/m1/s1
🔗 External References
HERB DB
HBIN048862 ↗
PubChem CID
5280899 ↗
NPASS
NPC45782;NPC491020
HIT
C0738
TCMID
32261
TCM-ID
24307
🔍 Raw view — every non-empty column on this row (30 fields)
name
Zeaxanthine
common names
Zeaxanthin; 144-68-3; Anchovyxanthin; Zeaxanthol; all-trans-Zeaxanthin; Xanthophyll 3; Beta,beta-carotene-3,3'-diol; Luteinofta; Optisharp; Zeagold
herb ingredient id
HBIN048862
canonical smiles
CC1=C(C(CC(C1)O)(C)C)C=CC(=CC=CC(=CC=CC=C(C)C=CC=C(C)C=CC2=C(CC(CC2(C)C)O)C)C)C
isomeric smiles
CC1=C(C(C[C@@H](C1)O)(C)C)/C=C/C(=C/C=C/C(=C/C=C/C=C(/C=C/C=C(/C=C/C2=C(C[C@H](CC2(C)C)O)C)\C)\C)/C)/C
inchi
InChI=1S/C40H56O2/c1-29(17-13-19-31(3)21-23-37-33(5)25-35(41)27-39(37,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-38-34(6)26-36(42)28-40(38,9)10/h11-24,35-36,41-42H,25-28H2,1-10H3/b12-11+,17-13+,18-14+,23-21+,24-22+,29-15+,30-16+,31-19+,32-20+/t35-,36-/m1/s1
inchikey
JKQXZKUSFCKOGQ-QAYBQHTQSA-N
mol wt
568.8860
num h acceptors
2
num h donors
2
mol logp
10.5474
num rotatable bonds
10
drug likeness
0.257
tcmid ingredient id
32261
tcm id ingredient id
24307
pubchem cid
5280899
npass id
NPC45782;NPC491020
hit id
C0738

🏥 Linked Health Topics

4 · diseases via target pathways
Macular Degeneration
syndrome
Cataract
disease
Exudative Age-Related Macular Degeneration
syndrome
Age-related macular degeneration
disease

📋 Clinical Trials

11 · subject of clinical study
NCT00121589 Lutein/Zeaxanthin and Omega-3 Supplementation in Persons Over Age 60
→ Macular Degeneration
NCT01528605 Effects of Lutein and Zeaxanthin Supplementation on Early Age-related Macular De
→ Age-related Macular Degeneration
NCT01621789 Efficacy of Lutein, Zeaxanthine and Trypan Blue to Stain the Anterior Lens Capsu
→ Cataract
NCT01627977 Association of Lutein, Zeaxanthin and Brilliant Blue in Chromovitrectomy
→ Epiretinal Membrane|Macular Hole|Proliferative Dia
NCT02200263 The Effects of Lutein and Zeaxanthin Supplementation on Vision in Patients With
→ Ocular Albinism (OA)|Oculocutaneous Albinism (OCA)
NCT00564902 The Zeaxanthin and Visual Function Study
→ Age Related Macular Degeneration|Cognition Disorde
NCT02017418 The Effects of a Zeaxanthin Intervention on Visuomotor Function
→ Behavior and Behavior Mechanisms
NCT00345176 Age-Related Eye Disease Study 2 (AREDS2)
→ Age-related Macular Degeneration|Cataract
NCT00763659 Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation on Optical D
→ Age Related Maculopathy
NCT01404845 Macular Pigment Density Evolution in Unilateral Wet AMD Versus Non AMD Patients
→ Exudative Age-related Macular Degeneration
NCT01648660 Long Term Effects of Lutein/Zeaxanthin and Omega-3- Supplementation for Two More
→ Age Related Maculopathy

📊 Meta-Analyses

4 · systematic review
CRD42016045942 Lutein and zeaxanthin for reducing morbidity and mortality in preterm infants [C
→ The Cochrane Neonatal Group
CRD42020197594 Systematic review of the evidence on lutein/zeaxanthin intake and human macular
→ optimal ocular tissue health
CRD42023485956 Assessment of biological carotenoid levels as biomarkers of dietary intake: a sy
→ Assessment of dietary intake is known to involve a
CRD42023449079 Complex of Lutein and Zeaxanthin to prevent Age-related Macular Degeneration(AMD
→ Age-related Macular Degeneration (AMD) is the lead

📚 PubMed References

3 · cited research
PMID 33689686 A novel gastroprotective effect of zeaxanthin against stress-induced gastritis i
Life Sci
PMID 34047728 Zeaxanthin promotes browning by enhancing mitochondrial biogenesis through the P
Food Funct
PMID 36500974 Evaluation of the Anti-Obesity Effect of Zeaxanthin and Exercise in HFD-Induced
Nutrients
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: ACTIVE — direct link via herb_ingredients
  • Ingredient ↔ Target: ACTIVE — direct link via ingredient_targets
  • Target ↔ Disease: ACTIVE — direct link via target_health_topics
  • Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables