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⚗️ Ingredient

3,5,3',5'-tetraiodothyronine

Open on HERB 2.0 ↗
48
Clinical Trials
34
Meta-Analyses
0
PubMed References
Top Conditions Studied with 3,5,3',5'-tetraiodothyronine
Hypothyroidism 11 Subclinical Hypothyroidism 6 Congenital Hypothyroidism 3 Pharmacokinetics 2 Bipolar Disorder 2 Levothyroxine. Drugs interactions. Malabsorption. 2 Hypothyroidism|Thyroid Diseases|Endocrine System Diseases 2 Positive thyroid antibodies, either thyroid peroxidase antib 1 Healthy Volunteers 1 Hypothyroidism is a common chronic disease caused by the ins 1 The condition being studied in your systematic review is hyp 1 Non-alcoholic fatty liver disease 1
📋 Sample Trials
NCT00498238
The Effect of Levothyroxine on Arterial Stiffness and Lipid Profile in Patients With Subclinical Hypothyroidism
Completed
NCT00941551
Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively
Completed
NCT01189344
Levothyroxine (L-T4) Absorption After Bariatric Surgery
Completed
📊 Sample Meta-Analyses
CRD42020047084
Concomitant use of levothyroxine and proton pump inhibitors in patients with primary hypothyroidism: a systematic review
Primary hypothyroidism and dyspepsia, gastroesophageal reflux or peptic ulcer.
CRD42017064796
Effect of levothyroxine treatment on chronic urticaria in euthyroid patients with thyroid autoantibodies
Efficacy of levothyroxine treatment on chronic urticaria in euthyroid patients w
CRD42017079808
The impact of levothyroxine therapy in pregnant women with subclinical hypothyroidism on obstetrical and childhood outcomes: systematic review and meta-analysis of randomized controlled trials
Subclinical hypothyroidism in pregnancy.
📚 Sample References
None linked yet.
⚗️ All Ingredient data fields for 3,5,3',5'-tetraiodothyronine
⚗️ Identity
Name
3,5,3',5'-tetraiodothyronine
Aliases / Synonyms
L-thyroxine; levothyroxine; 51-48-9; thyroxine; thyroxin; Levothyroxin; Tetraiodothyronine; 3,3',5,5'-Tetraiodo-L-thyronine; Thyratabs; Thyreoideum
🧪 Chemistry
Molecular Weight
776.8720
LogP
4.5573
Drug-likeness
0.388
H-Bond Acceptors
4
H-Bond Donors
3
Rotatable Bonds
5
🔬 Structures
Canonical SMILES
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
Isomeric SMILES
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
InChIKey
XUIIKFGFIJCVMT-LBPRGKRZSA-N
InChI
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
🔗 External References
HERB DB
HBIN007529 ↗
PubChem CID
5819 ↗
HIT
C0182
TCMID
21159
🔍 Raw view — every non-empty column on this row (28 fields)
name
3,5,3',5'-tetraiodothyronine
common names
L-thyroxine; levothyroxine; 51-48-9; thyroxine; thyroxin; Levothyroxin; Tetraiodothyronine; 3,3',5,5'-Tetraiodo-L-thyronine; Thyratabs; Thyreoideum
herb ingredient id
HBIN007529
canonical smiles
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)CC(C(=O)O)N
isomeric smiles
C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
inchi
InChI=1S/C15H11I4NO4/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23/h1-2,4-5,12,21H,3,20H2,(H,22,23)/t12-/m0/s1
inchikey
XUIIKFGFIJCVMT-LBPRGKRZSA-N
mol wt
776.8720
num h acceptors
4
num h donors
3
mol logp
4.5573
num rotatable bonds
5
drug likeness
0.388
tcmid ingredient id
21159
pubchem cid
5819
hit id
C0182

🏥 Linked Health Topics

6 · studied for these conditions (text bridge)
Bipolar Disorder
disease
Congenital Hypothyroidism
syndrome
Hypothyroidism
syndrome
Thyroid Nodule
disease
Subclinical Hypothyroidism
syndrome
Hashimoto Disease
syndrome

📋 Clinical Trials

12 · subject of clinical study
NCT00498238 The Effect of Levothyroxine on Arterial Stiffness and Lipid Profile in Patients
→ Subclinical Hypothyroidism
NCT00941551 Thyroid Lobectomy With or Without Levothyroxine Treatment Postoperatively
→ Recurrent Goiter
NCT01189344 Levothyroxine (L-T4) Absorption After Bariatric Surgery
→ Morbid Obesity
NCT01306227 L-Thyroxine Supplementation for Preterm Newborns Less Than 32 Weeks of Gestation
→ Hypothyroxinemia
NCT01465633 Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50
→ Pharmacokinetics
NCT01465646 Bioavailability Investigations of Thyronajod Mite Tablets of Dosage Strengths 50
→ Pharmacokinetics
NCT01528839 Supraphysiological Doses of Levothyroxine as Adjunctive Therapy in Bipolar Depre
→ Bipolar Disorder
NCT01631305 Levothyroxine for Children With Euthyroid Sick Syndrome
→ Euthyroid Sick Syndrome
NCT01831869 Effect of L-Thyroxine on Lipid Profiles and Atherosclerosis in Subclinical Hypot
→ Hypothyroidism|Thyroid Diseases|Endocrine System D
NCT01848171 Effects of L-thyroxine Replacement on Serum Lipid and Atherosclerosis in Hypothy
→ Hypothyroidism|Thyroid Diseases|Endocrine System D
NCT01916304 Study of Dose Adjustment From Levothyroxine to a New Levothyroxine Sodium Test F
→ Hypothyroidism
NCT01950260 Early Levothyroxine Post Radioactive Iodine
→ Graves' Disease

📊 Meta-Analyses

12 · systematic review
CRD42020047084 Concomitant use of levothyroxine and proton pump inhibitors in patients with pri
→ Primary hypothyroidism and dyspepsia, gastroesopha
CRD42017064796 Effect of levothyroxine treatment on chronic urticaria in euthyroid patients wit
→ Efficacy of levothyroxine treatment on chronic urt
CRD42017079808 The impact of levothyroxine therapy in pregnant women with subclinical hypothyro
→ Subclinical hypothyroidism in pregnancy.
CRD42018089578 Effectiveness of levothyroxine therapy on pregnancy outcomes in women with subcl
→ Levothyroxine therapy Levothyroxine therapy for su
CRD42018089670 Can levothyroxine change the pregnancy outcomes of women with normal thyroid fun
→ Levothyroxine  Pregnant women with normal thyroid
CRD42018093138 Effect of levothyroxine on blood pressure in patients with subclinical hypothyro
→ Subclinical hypothyroidism (SCH) is a state with e
CRD42018106182 Effect of levothyroxine on improvement in endothelial dysfunction in subclinical
→ Subclinical hypothyroidism
CRD42019123920 A systematic review of blinded randomized controlled trials examining how often
→ Hypothyroidism of any etiology (the cause of the h
CRD42019130459 The impact of levothyroxine in women with positive thyroid antibodies on pregnan
→ Positive thyroid antibodies, either thyroid peroxi
CRD42019132976 Effect of levothyroxine on pregnancy outcomes in women with thyroid autoimmunity
→ Thyroid Autoimmunity
CRD42019134798 Effect of levothyroxine supplementation on pregnancy outcomes in euthyroid women
→ Euthyroid women with thyroid autoimmuneity undergo
CRD42019141555 Effect of levothyroxine intervention on pregnancy outcomes in euthyroid women wi
→ The result of this analysis will provide informati
How relationships are computed
  • Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
  • Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
  • Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
  • Ingredient ↔ Target: empty — needs HERB_ingredient_target import
  • Target ↔ Disease: empty — needs HERB_target_disease import
  • Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables