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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

3,5,3'-triiodothyronine

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with 3,5,3'-triiodothyronine

Hypothyroidism 3 Healthy 2 Quality of Life|Depression 1 Autoimmune Hypothyroidism 1 Postoperative; Dysfunction Following Cardiac Surgery 1 Atrial Fibrillation 1 Multiple Sclerosis, Relapsing-Remitting|Multiple Sclerosis, 1 Major Depressive Disorder 1 Major Depression|Bipolar Disorder|Unipolar Depression 1 The condition being studied in your systematic review is hyp 1 Hypothyroidism|Biomarkers|Endocrine System Diseases 1 Hypothyroidism is a highly prevalent endocrine disorder whic 1

📋 Sample Trials

NCT00158990

Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression.

Completed · Phase 3

NCT00360074

Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatment and Triiodothyronine Supplementation

Completed · Phase 4

NCT00421369

Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response.

Completed

📊 Sample Meta-Analyses

CRD42020202658

Levothyroxine/liothyronine combination therapy versus levothyroxine monotherapy for treatment of hypothyroidism: Systematic review and meta-analysis

Hypothyroidism is a highly prevalent endocrine disorder which occurs as a conseq

CRD42023486957

Evaluating the Effectiveness of Combined T4 and T3 Therapy Versus Standard T4 Monotherapy and Desiccated Thyroid Versus Standard T4 Monotherapy in the Treatment of Hypothyroidism: A Systematic Review and Meta-Analysis

The condition being studied in your systematic review is hypothyroidism, a commo

📚 Sample References

PMID 23313345

Exogenous T3 administration provides neuroprotection in a murine model of traumatic brain injury

Pharmacol Res · 2013

PMID 32850840

Triiodothyronine Potentiates BMP9-Induced Osteogenesis in Mesenchymal Stem Cells Through the Activation of AMPK/p38 Signaling

Front Cell Dev Biol · 2020

PMID 32894141

Repositioning liothyronine for cancer immunotherapy by blocking the interaction of immune checkpoint TIGIT/PVR

Cell Commun Signal · 2020

⚗️ All Ingredient data fields for 3,5,3'-triiodothyronine

⚗️ Identity

Name

3,5,3'-triiodothyronine

Aliases / Synonyms

liothyronine; triiodothyronine; 3,3',5-Triiodo-L-thyronine; 6893-02-3; Liothyronin; Tresitope; 3,5,3'-Triiodo-L-thyronine; T3; triothyrone

🧪 Chemistry

Molecular Weight

650.9760

LogP

3.9527

Drug-likeness

0.427

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

Isomeric SMILES

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O

InChIKey

AUYYCJSJGJYCDS-LBPRGKRZSA-N

InChI

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

🔗 External References

HERB DB

HBIN007532 ↗

PubChem CID

5920 ↗

DrugBank

DB00279 ↗

TCMID

21852

🔍 Raw view — every non-empty column on this row (28 fields)

name

3,5,3'-triiodothyronine

common names

liothyronine; triiodothyronine; 3,3',5-Triiodo-L-thyronine; 6893-02-3; Liothyronin; Tresitope; 3,5,3'-Triiodo-L-thyronine; T3; triothyrone

herb ingredient id

HBIN007532

canonical smiles

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

isomeric smiles

C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)O)N)I)I)O

inchi

InChI=1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1

inchikey

AUYYCJSJGJYCDS-LBPRGKRZSA-N

mol wt

650.9760

num h acceptors

num h donors

mol logp

3.9527

num rotatable bonds

drug likeness

0.427

tcmid ingredient id

21852

pubchem cid

5920

drugbank id

DB00279

🏥 Linked Health Topics

4 · studied for these conditions (text bridge)

Subclinical Hypothyroidism

syndrome

Major Depressive Disorder

disease

📋 Clinical Trials

12 · subject of clinical study

NCT00158990 Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar D

→ Major Depression|Bipolar Disorder|Unipolar Depress

NCT00360074 Phase 4 Study in Secondary Hypothyroidism: Body Weight Adapted Thyroxin Treatmen

→ Secondary Hypothyroidism|Hypopituitarism|Hyperlipi

NCT00421369 Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T

→ Major Depressive Disorder

NCT00790738 Liothyronine (T3) for Bipolar Depression

→ Depression|Bipolar Disorder

NCT01481402 Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ven

→ Heart Failure|Low T3 Syndrome

NCT02506751 Open-label Study of Liothyronine in MS

→ Multiple Sclerosis, Relapsing-Remitting|Multiple S

NCT03053115 Combined Replacement Therapy With Levothyroxine and Liothyronine in Thyroidectom

→ Hypothyroidism

NCT03098433 Effects of Liothyronine on Energy Expenditure and Cardiovascular Function

→ Healthy

NCT02399475 Mechanistic Study of Subclinical Hypothyroidism In the Elderly

→ Subclinical Hypothyroidism

NCT00223158 Evaluation Study of L-T3 Utility in the Follow-up of Patients With Thyroid Cance

→ Thyroid Cancer

NCT00289367 Study of T3 on the Incidence of Atrial Fibrillation in Patients Undergoing Cardi

→ Atrial Fibrillation

NCT00531713 Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypot

→ Quality of Life|Depression

📊 Meta-Analyses

2 · systematic review

CRD42020202658 Levothyroxine/liothyronine combination therapy versus levothyroxine monotherapy

→ Hypothyroidism is a highly prevalent endocrine dis

CRD42023486957 Evaluating the Effectiveness of Combined T4 and T3 Therapy Versus Standard T4 Mo

→ The condition being studied in your systematic rev

📚 PubMed References

7 · cited research

PMID 23313345 Exogenous T3 administration provides neuroprotection in a murine model of trauma

Pharmacol Res

PMID 32850840 Triiodothyronine Potentiates BMP9-Induced Osteogenesis in Mesenchymal Stem Cells

Front Cell Dev Biol

PMID 32894141 Repositioning liothyronine for cancer immunotherapy by blocking the interaction

Cell Commun Signal

PMID 33876304 Cardioprotection by post-conditioning with exogenous triiodothyronine in isolate

Basic Res Cardiol

PMID 34715171 Triiodothyronine attenuates neurocognitive dysfunction induced by sevoflurane in

J Affect Disord

PMID 35697700 Triiodothyronine (T3) promotes brown fat hyperplasia via thyroid hormone recepto

Nat Commun

PMID 35808902 High triiodothyronine levels induce myocardial hypertrophy via BAFF overexpressi

J Cell Mol Med

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables