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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

4-hexyl alcohol acetate

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with 4-hexyl alcohol acetate

Peri-implant Mucositis 3 The intracanal disinfection protocol in the context of retai 1 In the intensive care units(ICU), most of the patients suffe 1 Antimicrobial effect of povidone-iodine scrub, chlorhexidine 1 Postoperative infections are a common complication of urogyn 1 Dental plaque accumulation 1 Dental Caries|Infection, Bacterial|Tooth, Deciduous 1 Urinary tract infections is the most common and perhaps the 1 Oral mucositis and xerostomia. 1 Cavities. The use of chlorhexidine as an antimicrobrial agen 1 The endodontic treatment comprises of cleaning,shaping, disi 1 In addition to mechanical control of plaque in orthodontic p 1

📋 Sample Trials

NCT05258955

Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mouthwash: A Randomized Controlled Trial

Completed · Phase 1

NCT05441605

Effect of Chlorhexidine Solution in Preventing Peripheral Venous Catheter Associated-Infection

Completed

NCT05548361

The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of Periodontitis

Recruiting

📊 Sample Meta-Analyses

CRD42013004000

For individuals with a high caries risk, does Cervitec (1% Chlorhexidine and 1% Thymol) varnish application when compared to placebo provide additional caries reduction?

Cervitec (1% Chlorhexidine and 1% Thymol) varnish application, caries prevention

CRD42014008955

The efficacy of daily chlorhexidine body bathing for reducing nosocomial infections in adult intensive care units

In the intensive care units(ICU), most of the patients suffered large trauma,cri

CRD42014014082

Effect of chlorhexidine on long-term clinical performance of adhesive restorations [protocol]

Adhesive restorations placed using chlorhexidine or not during the adhesive proc

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for 4-hexyl alcohol acetate

⚗️ Identity

Name

4-hexyl alcohol acetate

Aliases / Synonyms

chlorhexidine; 55-56-1; Rotersept; Fimeil; Hexadol; Soretol; Chlorhexidin; Chlorhexidinum; Cloresidina [DCIT]; Chlorhexidin [Czech]

🧪 Chemistry

Molecular Weight

505.4580

LogP

3.3366

Drug-likeness

0.173

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl

Isomeric SMILES

C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl

InChIKey

GHXZTYHSJHQHIJ-UHFFFAOYSA-N

InChI

InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

🔗 External References

HERB DB

HBIN010418 ↗

PubChem CID

9552079 ↗

TCMID

37674

🔍 Raw view — every non-empty column on this row (27 fields)

name

4-hexyl alcohol acetate

common names

chlorhexidine; 55-56-1; Rotersept; Fimeil; Hexadol; Soretol; Chlorhexidin; Chlorhexidinum; Cloresidina [DCIT]; Chlorhexidin [Czech]

herb ingredient id

HBIN010418

canonical smiles

C1=CC(=CC=C1NC(=NC(=NCCCCCCN=C(N)N=C(N)NC2=CC=C(C=C2)Cl)N)N)Cl

isomeric smiles

C1=CC(=CC=C1N/C(=N/C(=NCCCCCCN=C(/N=C(/NC2=CC=C(C=C2)Cl)\N)N)N)/N)Cl

inchi

InChI=1S/C22H30Cl2N10/c23-15-5-9-17(10-6-15)31-21(27)33-19(25)29-13-3-1-2-4-14-30-20(26)34-22(28)32-18-11-7-16(24)8-12-18/h5-12H,1-4,13-14H2,(H5,25,27,29,31,33)(H5,26,28,30,32,34)

inchikey

GHXZTYHSJHQHIJ-UHFFFAOYSA-N

mol wt

505.4580

num h acceptors

num h donors

mol logp

3.3366

num rotatable bonds

drug likeness

0.173

tcmid ingredient id

37674

pubchem cid

9552079

🏥 Linked Health Topics

3 · studied for these conditions (text bridge)

Peri-Implant Mucositis

syndrome

📋 Clinical Trials

9 · subject of clinical study

NCT05258955 Title: Comparison of Anti-plaque Efficacy of Natural Honey With Chlorhexidine Mo

→ Dental Plaque

NCT05441605 Effect of Chlorhexidine Solution in Preventing Peripheral Venous Catheter Associ

→ Catheter-Associated Infections

NCT05548361 The Use of Chlorhexidine and a Probiotic Lozenge in the Nonsurgical Therapy of P

→ Periodontitis|Chlorhexidine|Probiotic

NCT05254275 Ozoral Pro and Ozoral Gel vs Chlorhexidine Gel 1% for the Management of Peri-imp

→ Peri-implant Mucositis

NCT05256914 Ozonized In-office and Domiciliary Gels vs Chlorhexidine Gel 1% for the Manageme

→ Peri-implant Mucositis

NCT05312593 Domiciliary Use of Hyaluronic Acid Gel Solutions vs Domiciliary Use of Chlorhexi

→ Peri-implant Mucositis

NCT05206721 Open Suction Circuit Flushing With Chlorhexidine Decreases Ventilator-Associated

→ Ventilator Associated Pneumonia

NCT05312606 Domiciliary Use of Hyaluronic Acid Gel Solutions vs Domiciliary Use of Chlorhexi

→ Periodontal Diseases

NCT05361278 Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of P

→ Dental Caries|Infection, Bacterial|Tooth, Deciduou

📊 Meta-Analyses

12 · systematic review

CRD42013004000 For individuals with a high caries risk, does Cervitec (1% Chlorhexidine and 1%

→ Cervitec (1% Chlorhexidine and 1% Thymol) varnish

CRD42014008955 The efficacy of daily chlorhexidine body bathing for reducing nosocomial infecti

→ In the intensive care units(ICU), most of the pati

CRD42014014082 Effect of chlorhexidine on long-term clinical performance of adhesive restoratio

→ Adhesive restorations placed using chlorhexidine o

CRD42014014283 Chlorhexidine based interventions used to prevent catheter-associated urinary tr

→ Urinary tract infections is the most common and pe

CRD42014014973 Effect of daily chlorhexidine body washing to control bacteriaemia in intensive

→ Multidrug-resistant organisms and hospital acquire

CRD42015023395 Effects of chlorhexidine varnish on caries during orthodontic treatment: a syste

→ Caries is a multifactorial condition with clinical

CRD42015027025 The sterilization effects and adverse events of chlorhexidine when collecting bl

→ The sterilization effects produced by chlorhexidin

CRD42015027663 Chlorhexidine versus sodium hypochlorite for decontamination of root canals: a s

→ The endodontic treatment comprises of cleaning,sha

CRD42016032505 Chlorhexidine Gluconate as an antiseptic skin solution for the prevention of cat

→ The effectiveness of chlorhexidine gluconate as an

CRD42015032523 Chlorhexidine bathing to reduce nosocomial bloodstream infections: a systematic

→ Bloodstream infections and catheter related infect

CRD42016038208 Effectiveness of alcoholic chlorhexidine skin antisepsis to reduce surgical site

→ Globally, 310 million patients undergo major surge

CRD42016045961 Chlorhexidine bathing of the critically ill for the prevention of hospital-acqui

→ The Cochrane Wounds Group

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables