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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

4-pregnene-17α,20β,21-triol-3,11-dione

Open on HERB 2.0 ↗

125

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with 4-pregnene-17α,20β,21-triol-3,11-dione

Septic Shock 10 Adrenal Insufficiency 8 Prostate Cancer 5 Psoriasis Vulgaris 4 Sepsis 3 Healthy 3 Bronchopulmonary Dysplasia 2 Septic shock. 2 Congenital Adrenal Hyperplasia 2 Knee osteoarthritis 1 PTSD|Acute Stress Disorder|Trauma-related Stressor 1 Impacted Third Molar Tooth 1

📋 Sample Trials

NCT00002881

Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer

Completed · Phase 3

NCT00004669

Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary Dysplasia

Completed · Phase 2

NCT00097474

Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

Completed · Phase 2

📊 Sample Meta-Analyses

CRD42017062198

Effects of hydrocortisone and hydrocortisone plus fludrocortisone in adults with septic shock

We will consider adults with septic shock as defined in individual trials.

CRD42017073615

Efficacy and safety of systemic hydrocortisone for the prevention of chronic lung disease: a systematic review and meta-analysis

Bronchopulmonary dysplasia (BPD) of prematurity.

CRD42018090792

The effects of low dose hydrocortisone in patients with sepsis or septic shock

Patients with sepsis or septic shock.

📚 Sample References

None linked yet.

⚗️ All Ingredient data fields for 4-pregnene-17α,20β,21-triol-3,11-dione

⚗️ Identity

Name

4-pregnene-17α,20β,21-triol-3,11-dione

Aliases / Synonyms

hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort; Cortef; Hydrasson; Hydrocortisyl; Hydrocortone; Cobadex

🧪 Chemistry

Molecular Weight

362.4660

LogP

1.7816

Drug-likeness

0.696

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O

Isomeric SMILES

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

InChIKey

JYGXADMDTFJGBT-VWUMJDOOSA-N

InChI

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

🔗 External References

HERB DB

HBIN010825 ↗

PubChem CID

5754 ↗

NPASS

NPC18509

HIT

C0129

TCMID

17790

🔍 Raw view — every non-empty column on this row (29 fields)

name

4-pregnene-17α,20β,21-triol-3,11-dione

common names

hydrocortisone; Cortisol; 50-23-7; Acticort; Cetacort; Cortef; Hydrasson; Hydrocortisyl; Hydrocortone; Cobadex

herb ingredient id

HBIN010825

canonical smiles

CC12CCC(=O)C=C1CCC3C2C(CC4(C3CCC4(C(=O)CO)O)C)O

isomeric smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O

inchi

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m0/s1

inchikey

JYGXADMDTFJGBT-VWUMJDOOSA-N

mol wt

362.4660

num h acceptors

num h donors

mol logp

1.7816

num rotatable bonds

drug likeness

0.696

tcmid ingredient id

17790

pubchem cid

5754

npass id

NPC18509

hit id

C0129

🏥 Linked Health Topics

12 · studied for these conditions (text bridge)

Congenital Adrenal Hyperplasia

syndrome

Alopecia Areata

syndrome

Bronchopulmonary Dysplasia

📋 Clinical Trials

12 · subject of clinical study

NCT00002881 Flutamide, Suramin, and Hydrocortisone in Treating Patients With Prostate Cancer

→ Prostate Cancer

NCT00004669 Phase II Pilot Study of Early Cortisol Replacement to Prevent Bronchopulmonary D

→ Bronchopulmonary Dysplasia

NCT00097474 Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag

→ Jet Lag

NCT00149123 Low-dose Hydrocortisone in Acutely Burned Patients

→ Burns

NCT00167544 Randomized Trial of Hydrocortisone in Very Preterm High-Risk Infants

→ Bronchopulmonary Dysplasia|Encephalomalacia|Premat

NCT00172354 Hydrocortisone in Patients of Out-of-hospital Cardiac Arrest

→ Heart Arrest

NCT00185783 Impact of Hydrocortisone Administration on White Blood Cell Gene Expression in P

→ Sepsis|Relative Adrenal Insufficiency

NCT00186264 Does Concurrent Hydrocortisone With Venlafaxine XR Speed Antidepressant Response

→ Depressive Disorder, Major

NCT00236925 Efficacy Study of Low-Dose Hydrocortisone Treatment for Fibromyalgia

→ Fibromyalgia

NCT00309894 Ketoconazole, Hydrocortisone, and GM-CSF in Treating Patients With Progressive P

→ Prostate Cancer

NCT00358748 Early Use of Hydrocortisone in Hypotensive Very Low Birth Weight Infants

→ Neonatal Hypotension

NCT00396344 Cortisol Control of Human Inflammatory Responses to Endotoxin

→ Sepsis

📊 Meta-Analyses

12 · systematic review

CRD42017062198 Effects of hydrocortisone and hydrocortisone plus fludrocortisone in adults with

→ We will consider adults with septic shock as defin

CRD42017073615 Efficacy and safety of systemic hydrocortisone for the prevention of chronic lun

→ Bronchopulmonary dysplasia (BPD) of prematurity.

CRD42018090792 The effects of low dose hydrocortisone in patients with sepsis or septic shock

→ Patients with sepsis or septic shock.

CRD42018100112 Impact of hydrocortisone in sepsis and septic shock on mortality. A protocol of

→ The included conditions are sepsis or septic shock

CRD42018108509 The metabolic effects of once daily modified release hydrocortisone vs standard

→ Adrenal insufficiency is an endocrinopathy resulti

CRD42019139069 Fludrocortisone with hydrocortisone for adult patients with septic shock

→ Septic shock

CRD42019139343 Effect of hydrocortisone for adults patients with septic shock unresponsive to i

→ Septic shock.

CRD42020170648 Effect of combined vitamin C, hydrocortisone and thiamine for patients with sept

→ Nowadays, the mortality rate of septic shock remai

CRD42020203166 Hydrocortisone, ascorbic acid and thiamine for sepsis and septic shock: a meta-a

→ The effect of treatment with hydrocortisone, ascor

CRD42020207832 Combined treatment with ascorbic acid, hydrocortisone, and thiamine for patients

→ Sepsis rapidly progresses causing multiple organ d

CRD42020216665 Benefit of hydrocortisone, thiamine, and vitamin C for patients with sepsis or s

→ Sepsis/ septic shock requiring vasopressor/ inotro

CRD42020220036 The Effectiveness of One or Combination of Vitamin C or Thiamine or Hydrocortiso

→ Description of The Condition Sepsis, if unable to

How relationships are computed

Clinical Trials / Meta-Analyses / References: direct foreign-key link via subject_entity_id (Phase 2d wireup)
Formula ↔ Herbs: text bridge via formulas.herbs_in_pinyin matching herbs.pinyin_name
Herb ↔ Ingredient: empty — needs HERB_herb_ingredient import
Ingredient ↔ Target: empty — needs HERB_ingredient_target import
Target ↔ Disease: empty — needs HERB_target_disease import
Herb → Target → Disease (full chemical spine): awaiting Phase 2e link tables