Relationship Graph Explorer
Follow the connections
Every herb, ingredient, formula, gene target, and disease — connected through real research. Search, pick a subject, and navigate the graph in any direction.
🌿
Herb
6,826
→
⚗️
Ingredient
44,598
→
🧬
Gene Target
15,695
→
🏥
Disease
30,467
→
🧪
Evidence
23,295
trials · metas · refs
Plus 6,743 TCM formulas connecting herbs together
11 Diseases matching "Down Syndrome"
Down Syndrome
Down Syndrome Critical Region
Down Syndrome, Partial Trisomy 21
Trisomy 21, Mitotic Nondisjunction
Trisomy 21, Meiotic Nondisjunction
Myeloproliferative Syndrome, Transient
Leukemia, Megakaryoblastic, of Down Syndrome
Myeloid Leukemia Associated With Down Syndrome
Myeloid Proliferations Associated With Down Syndro
Transient Myeloproliferative Disorder of Down Synd
Cataracts, Congenital, With Sensorineural Deafness
🏥 Disease / Health Topic
Down Syndrome
6
Clinical Trials
2
Meta-Analyses
0
PubMed References
📋 Sample Trials
NCT01699711
Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Performance and Decelerate AD Progression in DS Subjects: Epigallocatechin Gallate as Therapeutic Tool
Completed · Phase 2
NCT00294593
Efficacy Study of Folinic Acid to Improve Mental Development of Children With Down Syndrome
Completed · Phase 2|Phase 3
NCT01576705
Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormone on Psychomotor Development of Down Syndrome Young Children
Completed · Phase 3
📊 Sample Meta-Analyses
CRD42020159274
Dysregulation of tryptophan-kynurenine pathway associated metabolites in patients with dementia or cognitive impairment: a meta-analysis
Dementia, cognitive and affective symptomology, and aging. Dementia is an overal
CRD42020159274
Dysregulation of tryptophan-kynurenine pathway associated metabolites in patients with dementia or cognitive impairment: a meta-analysis
Dementia, cognitive and affective symptomology, and aging. Dementia is an overal
📚 Sample References
None linked yet.
🏥 All Disease / Health Topic data fields for Down Syndrome
🏥 Names
Disease Name
Down Syndrome
Alias Names
Down Syndrome, Partial Trisomy 21; Down Syndrome Critical Region; Transient Myeloproliferative Disorder of Down Syndrome; Down'S Syndrome, Unspecified; Down'S Syndrome; Leukemia, Megakaryoblastic, of Down Syndrome; Trisomy 21, Mitotic Nondisjunction; Trisomy 21, Meiotic Nondisjunction; Down Syndrome
Topic Type
syndrome
🧬 Ontology Classifications
DisGeNET Type
disease
UMLS Type
Disease or Syndrome
MeSH Class
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
DO Class
genetic disease
🔗 External References
HERB DB
MeSH
ICD-10
OMIM
Disease Ontology
14250
DisGeNET
C0013080
🔍 Raw view — every non-empty column on this row (28 fields)
name
Down Syndrome
alias name
Down Syndrome, Partial Trisomy 21; Down Syndrome Critical Region; Transient Myeloproliferative Disorder of Down Syndrome; Down'S Syndrome, Unspecified; Down'S Syndrome; Leukemia, Megakaryoblastic, of Down Syndrome; Trisomy 21, Mitotic Nondisjunction; Trisomy 21, Meiotic Nondisjunction; Down Syndrome
topic type
syndrome
disgenet disease type
disease
umls disease type
Disease or Syndrome
mesh disease class
Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Nervous System Diseases
do disease class
genetic disease
umls disease type id
T047
mesh disease class id
C16; C10
do disease class id
DOID:630
herb disease id
HBDIS000821
disgenet id
C0013080
mesh id
D004314
do id
14250
icd10 id
Q90; Q90.9
omim id
190685
⚗️ Related Ingredients
5 · compounds in this herb📋 Clinical Trials
6 · subject of clinical studyNCT01699711 Normalization of dyrk1A and APP Function as an Approach to Improve Cognitive Per
→ Down Syndrome (DS)
NCT00294593 Efficacy Study of Folinic Acid to Improve Mental Development of Children With Do
→ Down Syndrome
NCT01576705 Efficacy Assessment of Systematic Treatment With Folinic Acid and Thyroid Hormon
→ Down Syndrome
NCT01778946 Nicotine Treatment of Cognitive Decline in Down Syndrome
→ Down Syndrome|Mild Cognitive Impairment
NCT01594346 Multicenter Vitamin E Trial in Aging Persons With Down Syndrome
→ Alzheimer's Disease|Down Syndrome
NCT01832753 Treatment Trial of Subclinical Hypothyroidism in Down Syndrome
→ Down Syndrome|Subclinical Hypothyroidism
📊 Meta-Analyses
2 · systematic reviewCRD42020159274 Dysregulation of tryptophan-kynurenine pathway associated metabolites in patient
→ Dementia, cognitive and affective symptomology, an
CRD42020159274 Dysregulation of tryptophan-kynurenine pathway associated metabolites in patient
→ Dementia, cognitive and affective symptomology, an
How relationships are computed
- Clinical Trials / Meta-Analyses / References: direct foreign-key link via
subject_entity_id(Phase 2d wireup) - Formula ↔ Herbs: text bridge via
formulas.herbs_in_pinyinmatchingherbs.pinyin_name - Herb ↔ Ingredient:
ACTIVE — direct link via
herb_ingredients - Ingredient ↔ Target:
ACTIVE — direct link via
ingredient_targets - Target ↔ Disease:
ACTIVE — direct link via
target_health_topics - Herb → Target → Disease (full chemical spine): ACTIVE — joins all three link tables