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Evidence

23,295

trials · metas · refs

Plus 6,743 TCM formulas connecting herbs together

Subject Type: 🌿 Herbs ⚗️ Ingredients 📜 Formulas 🧬 Targets 🏥 Diseases

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⚗️ Ingredient

Deoxycholic acid

Open on HERB 2.0 ↗

Clinical Trials

Meta-Analyses

PubMed References

Top Conditions Studied with Deoxycholic acid

Moderate or Severe Submental Fullness 9 Moderate to Severe Convexity of Submental Fat|Safety|Efficac 2 Lipoma 2 Brassiere Strap Fat (BSF)|Bra Strap Fat (BSF) 1 The loss of the chin profile due to the accumulation of subm 1 Adiposity 1 Submental fat, also known as the double chin, is excess fat 1 Submental fat can negatively impact facial appearance, as we 1 Studies which explored the applications of injectable deoxyc 1 Upper Back Fat 1 Subcutaneous Fat 1 Neurofibromatosis 1 1

📋 Sample Trials

NCT00422188

Deoxycholic Acid Injection for the Treatment of Superficial Lipomas

Completed · Phase 1

NCT00618618

Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat

Completed · Phase 2

NCT00618722

Phase 1-2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Submental Fat

Completed · Phase 1|Phase 2

📊 Sample Meta-Analyses

CRD42020213873

Efficacy and safety of ATX-101(deoxycholic acid ) for reduction of submental fat: A systematic review and meta-analysis.

Submental fat, also known as the double chin, is excess fat between the neck and

CRD42021232313

Is deoxycholic acid able to reduce submental fat and increase patient satisfaction when compared to the placebo group? Systematic review with meta-analysis.

Submental fat can negatively impact facial appearance, as well as the patient's

CRD42021234515

The effect of ATX-101 (deoxycholic acid) on the reduction of submental fat: A systematic review.

The loss of the chin profile due to the accumulation of submental fat is an aest

📚 Sample References

PMID 31963815

Four-And-A-Half LIM-Domain Protein 2 (FHL2) Deficiency Aggravates Cholestatic Liver Injury

Cells · 2020

PMID 28202625

Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity

Cancer Discov · 2017

PMID 27630169

Galectin-3 regulates inflammasome activation in cholestatic liver injury

FASEB J · 2016

⚗️ All Ingredient data fields for Deoxycholic acid

⚗️ Identity

Name

Deoxycholic acid

Aliases / Synonyms

83-44-3; Desoxycholic acid; deoxycholate; Cholerebic; Cholorebic; Choleic acid; Degalol; Deoxycholatic acid; Droxolan

🧪 Chemistry

Molecular Weight

392.5800

LogP

4.4779

Drug-likeness

0.659

Oral Bioavailability

40.7230

H-Bond Acceptors

H-Bond Donors

Rotatable Bonds

🔬 Structures

Canonical SMILES

CC(CCC(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C

Isomeric SMILES

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

InChIKey

KXGVEGMKQFWNSR-LLQZFEROSA-N

InChI

InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

🔗 External References

HERB DB

HBIN023356 ↗

PubChem CID

222528 ↗

CAS Number

83-44-3 ↗

NPASS

NPC157337

TCMID

23208; 5160

TCMSP

MOL008845

🔍 Raw view — every non-empty column on this row (31 fields)

name

Deoxycholic acid

common names

83-44-3; Desoxycholic acid; deoxycholate; Cholerebic; Cholorebic; Choleic acid; Degalol; Deoxycholatic acid; Droxolan

herb ingredient id

HBIN023356

canonical smiles

CC(CCC(=O)O)C1CCC2C1(C(CC3C2CCC4C3(CCC(C4)O)C)O)C

isomeric smiles

C[C@H](CCC(=O)O)[C@H]1CC[C@@H]2[C@@]1([C@H](C[C@H]3[C@H]2CC[C@H]4[C@@]3(CC[C@H](C4)O)C)O)C

inchi

InChI=1S/C24H40O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-21,25-26H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-/m1/s1

inchikey

KXGVEGMKQFWNSR-LLQZFEROSA-N

mol wt

392.5800

num h acceptors

num h donors

mol logp

4.4779

num rotatable bonds

drug likeness

0.659

ob score

40.7230

cas id

83-44-3

tcmid ingredient id

23208; 5160

tcmsp ingredient id

MOL008845

pubchem cid

222528

npass id

NPC157337

🏥 Linked Health Topics

3 · diseases via target pathways

📋 Clinical Trials

12 · subject of clinical study

NCT00422188 Deoxycholic Acid Injection for the Treatment of Superficial Lipomas

→ Lipoma

NCT00618618 Phase 2 Study of Deoxycholic Acid Injection (ATX-101) for the Reduction of Subme