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Probiotics in Pregnancy and Breastfeeding: What Is Known and What to Check

What reviews show about the safety of probiotics in pregnancy and breastfeeding, what trials found for gestational diabetes and mastitis, and what official advice does and does not say.

Content last updated . This page has not been medically reviewed.

Start here: who to ask, and what is not a probiotic job

Pregnancy and breastfeeding questions about any supplement belong with a midwife, obstetrician or pharmacist. NCCIH advises consulting a health care provider before a probiotic supplement and not using probiotics as a reason to delay seeing a provider about a health problem. [1] The NHS (UK) says that if you have an existing health condition or a weakened immune system you should talk to a doctor before taking probiotic supplements. [2] A change in vaginal discharge in pregnancy should be checked: the NHS says to speak to a GP or midwife. [3] Probiotics do not replace treatment for infections; contact your maternity team about any worrying symptom rather than trying a supplement first.

Official advice: what we could and could not read

Official advice written specifically about probiotic supplements in pregnancy: not described in the sources we read. The NHS probiotics page and the NHS pregnancy pages we read (foods to avoid, healthy diet) do not give a pregnancy-specific rule for probiotic supplements. The US Office of Dietary Supplements fact sheet could not be read (the page returned an access error), so we do not quote it. What we did read:
  • The NHS says that for most people probiotics appear to be safe, but products are classed as food rather than medicine, so we cannot always be sure what is in them. [2]
  • NCCIH notes that some products have been reported to contain organisms not on the label, and that the risk of harm is greater in people with severe illness or weakened immune systems. [1]
  • The NHS pregnancy food page says unpasteurised or soft ripened dairy foods may contain listeria, which can cause listeriosis, and lists pasteurised yoghurt under foods that are safe to eat. [4] That is about fermented dairy foods, not supplements; see Yogurt and Fermented Foods Safety.

Evidence labels

Promising but limited (small or few trials), mixed, insufficient evidence, no good evidence of benefit. Every result below is for particular strains and trial designs, not for probiotics in general.

What reviews found

QuestionWhat the source foundLabel
Is it safe in pregnancy and breastfeeding?A 2021 systematic review concluded probiotic and prebiotic products are safe in pregnancy and lactation, with adverse effects not posing serious concern to mother or infant [5]. Only 11 of 100 eligible studies reported adverse effects in a form that could be analyzed [5], and one study reported more vaginal discharge and stool changes with Lactobacillus rhamnosus and L. reuteri [5]. Absence of reported harm is not proof of safetyLimited reporting; no serious concern found
Pregnancy and birth outcomesA 2021 meta-analysis of randomized trials found no positive or negative effect on perinatal outcomes, and said outcome reporting was highly inconsistent [6]No good evidence of benefit or harm
Preventing gestational diabetesA 2014 Cochrane review could include only one study of 256 women and judged there were too few studies for a quantitative meta-analysis [7]Insufficient
Women who already have gestational diabetesA 2017 meta-analysis of four trials (288 women, 6 to 8 weeks) found no effect on fasting glucose or LDL-cholesterol but a lower insulin-resistance score (HOMA-IR), and called for longer, higher-quality studies before routine use [8]. A lab marker is not a clinical outcomePromising but limited
Mastitis after childbirthA 2020 Cochrane review said probiotics may be better than placebo but that a large unpublished trial made the evidence incomplete [9]. A 2022 meta-analysis of six trials found fewer cases of mastitis and called for high-quality multicenter trials [10]Promising but limited
Baby's eczema riskNCCIH describes a 2015 review of 17 studies of probiotics in pregnancy or early infancy that found lower atopic dermatitis risk, especially with mixtures, but no effect on asthma, wheezing or hay fever [1]. The NHS says there is no evidence probiotics help treat eczema [2]Mixed

For more on gestational diabetes diet and prenatal supplements, see Prenatal and Postnatal Vitamins and Preconception, Pregnancy, Postpartum and Breastfeeding. Eczema trials are on Probiotics for Eczema, Food Allergy and Asthma in Children.

Frequently asked questions

Are probiotics safe during pregnancy?

A 2021 systematic review found no serious safety concern, but only a minority of studies reported adverse effects in analyzable form. [5] Official pregnancy-specific advice was not described in the sources we read, so ask a midwife or obstetrician.

Do probiotics prevent gestational diabetes?

A 2014 Cochrane review found too few studies to say. [7]

Can probiotics prevent mastitis while breastfeeding?

Some trials suggest fewer cases, but the Cochrane review calls the evidence incomplete. [9][10] Mastitis with fever or a hard, red, painful breast needs a clinician.

Is yogurt safe in pregnancy?

The NHS lists pasteurised yoghurt under foods that are safe to eat and says unpasteurised dairy may carry listeria. [4] That page does not discuss live cultures or probiotic benefit.

Will a probiotic in pregnancy prevent my baby's eczema?

Some reviews found lower risk of atopic dermatitis but no effect on asthma or hay fever. [1] It is not a guarantee, and strain matters.

More details: evidence, limits and cautions

The details behind this page: cautions, limits of the evidence and where sources disagree. Open any note to read it.

Vaginal infections in pregnancy
The NHS says bacterial vaginosis is usually treated with antibiotics and that it is important to seek treatment in pregnancy because of a small chance of complications. [3] A 2025 network meta-analysis found oral probiotics ranked highest for preterm delivery risk reduction but with low-quality evidence, and said current evidence does not endorse treating BV in pregnancy to reduce preterm delivery. [11] Do not use a probiotic in place of prescribed treatment. See Probiotics for Vaginal Health.
Cautions
  • Immunocompromise, central lines, serious illness: ask the care team first. [1]
  • A newborn who is premature should not be given probiotics at home: the FDA warns of invasive, potentially fatal disease in preterm infants. [12] A mother's use during breastfeeding is a different question and the sources above do not address a baby's exposure through milk in a way we could verify.
  • Product quality and medicine interactions: Probiotic Label Accuracy, Medication Interactions.
  • Proper evidence not found in the sources we read for: probiotic dose, timing or strain choice during pregnancy, and for differences between trimesters.
References
  1. NCCIH (US National Center for Complementary and Integrative Health). Probiotics: Usefulness and Safety. Read 2026-10-23.
  2. NHS (UK). Probiotics (page last reviewed 24 November 2022). Read 2026-10-23.
  3. NHS (UK). Bacterial vaginosis. Read 2026-10-23.
  4. NHS (UK). Foods to avoid in pregnancy. Read 2026-10-23.
  5. Are probiotics and prebiotics safe for use during pregnancy and lactation? A systematic review and meta-analysis. Nutrients 2021. PubMed 34371892 (abstract). Read 2026-10-23.
  6. Reporting of perinatal outcomes in probiotic randomized controlled trials: a systematic review and meta-analysis. Nutrients 2021. PubMed 33477352 (abstract). Read 2026-10-23.
  7. Cochrane review. Probiotics for preventing gestational diabetes. Cochrane Database Syst Rev 2014. PubMed 24574258 (abstract). Read 2026-10-23.
  8. Effect of probiotics on metabolic outcomes in pregnant women with gestational diabetes: a systematic review and meta-analysis of randomized controlled trials. Nutrients 2017. PubMed 28475161 (abstract). Read 2026-10-23.
  9. Cochrane review. Interventions for preventing mastitis after childbirth. Cochrane Database Syst Rev 2020. PubMed 32987448 (abstract). Read 2026-10-23.
  10. The preventive and therapeutic effects of probiotics on mastitis: a systematic review and meta-analysis. PLoS One 2022. PubMed 36084006 (abstract). Read 2026-10-23.
  11. Effects of bacterial vaginosis treatment during pregnancy on maternal-fetal outcome: a systematic review and network meta-analysis. Eur J Obstet Gynecol Reprod Biol 2025. PubMed 39946993 (abstract). Read 2026-10-23.
  12. FDA (US Food and Drug Administration). Risk of Invasive Disease in Preterm Infants Given Probiotics Formulated to Contain Live Bacteria or Yeast (safety communication, 2023). Read 2026-10-23.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.