Drug-Induced Liver Disease

Nutrients connected to Drug-Induced Liver Disease

A link means the body needs the nutrient for this, or that low intake is linked to it. It does not mean extra supplements help if your intake is already adequate; each link shows how strong the evidence is.

• AshwagandhaDocumented risk

  Case series document herb-induced liver injury, usually cholestatic, mostly recovering after stopping but fatal in some people with existing chronic liver disease.

• TurmericDocumented risk

  Turmeric products, especially highly absorbable curcumin products, have been linked to liver injury, including one death in a US series of ten cases.

• Gotu kolaDocumented risk

  Case reports describe herb-induced hepatitis and jaundice after gotu kola; frequency is unknown.

• Guduchi (giloy)Documented risk

  Herb-induced liver injury has been reported with guduchi; cause (authentic plant or look-alike species) is debated.

• He shou wuDocumented risk

  Case series and reviews document herb-induced liver injury from this root; all 18 people in one series improved after stopping it.

• Vitamin B3 (niacin)Documented risk

  Long-term high doses of niacin could lead to liver damage.

• Green tea extract and EGCGDocumented risk

  Liver injury has been reported in people using green tea extract supplements; it is uncommon, and some people may be more susceptible because of genes.

• Pelargonium (Umckaloabo)Documented risk

  Liver problems have been reported with unknown frequency; a 2012 review of 13 reports could not establish the plant as the cause.

• Black cohoshDocumented risk

  Rare cases of liver injury have been reported with black cohosh products; it is uncertain whether the herb caused them.

• TribulusDocumented risk

  Case reports describe severe liver injury with tribulus products.

• Botanical and mushroom nootropicsDocumented risk

  Rare liver injury has been linked to ashwagandha (named on the group page); bacopa, ginkgo and lion's mane were not linked to clinically apparent injury in LiverTox.

• ValerianDocumented risk

  Rare liver injury has been reported, most often with other herbs.

• Asian ginsengDocumented risk

  Liver damage reported as uncommon; case reports with imatinib.

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