Holistic Remedies · Ingredient
Coumarins
Formula: C19H16O4 · MW: 308.333 · Drug-likeness: 0.748
⚗️ Identity
Name
Coumarins
Aliases / Synonyms
warfarin; 81-81-2; Coumadin; Coumafene; Zoocoumarin; Coumafen; Brumolin; Coumefene; Kypfarin; Solfarin
🧪 Chemistry
Molecular Weight
308.3330
LogP
3.6096
Drug-likeness
0.748
H-Bond Acceptors
4
H-Bond Donors
1
Rotatable Bonds
4
🔗 External References
153
Clinical Trials
0
Meta-Analyses
1
PubMed References
Top Conditions Studied with Coumarins
Healthy 22
Atrial Fibrillation 20
Thromboembolism 7
Healthy Volunteers 5
Type 2 Diabetes Mellitus 3
Neoplasms 2
Stroke|Venous Thrombosis|Atrial Fibrillation|Atrial Flutter 2
Atrial Fibrillation|Stroke 2
Diabetes Mellitus, Type 2 2
Anticoagulation 2
Pulmonary Arterial Hypertension 1
Drug Therapy, Combination 1
📋 Sample Trials
NCT02254148
The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)
Completed · Phase 1 · Healthy
NCT04679948
A Study in Healthy People to Test Whether BI 730357 Influences the Amount of Caffeine, Warfarin, Omeprazole, and Midazolam in the Blood
Completed · Phase 1 · Healthy
NCT00007683
Warfarin and Antiplatelet Therapy in Chronic Heart Failure
Completed · Phase 3 · Heart Failure
NCT00014352
Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer
Completed · Phase 2 · Prostate Cancer|Thromboembolism
NCT00024297
Warfarin in Preventing Blood Clots in Cancer Patients With Central Venous Catheters
Completed · Thromboembolism
NCT00027066
Warfarin Versus Aspirin Recurrent Stroke Study
Completed · Phase 3 · Stroke
📊 Sample Meta-Analyses
None linked yet.
📚 Sample References
PMID 33901456
Warfarin Induces Calcification of the Aortic Valve Through Extracellular Signal-regulated Kinase 1/2 and β-catenin Signaling
Ann Thorac Surg · 2021
🏥 Linked Health Topics 12 · matched via study conditions
Alzheimer'S Disease
syndrome
Atherosclerosis
syndrome
Atrial Fibrillation
syndrome
Blood Coagulation Disorders
group
Epilepsy
syndrome
Heart Failure
syndrome
Hypertriglyceridemia
phenotype
Myocardial Infarction
syndrome
Neoplasms
group
Psoriasis
syndrome
Thromboembolism
phenotype
Venous Thrombosis
phenotype