Holistic Remedies · Ingredient
Hesperidin
Formula: C28H34O15 · MW: 610.5650000000007 · Drug-likeness: 0.185
⚗️ Identity
Name
Hesperidin
Aliases / Synonyms
520-26-3; Cirantin; Hesperidoside; Hesper bitabs; Hesperetin 7-rhamnoglucoside; Hesperetin-rutinosid; Hesperidine; Hesperetin 7-rutinoside; Ciratin
🧪 Chemistry
Molecular Weight
610.5650
LogP
-1.1566
Drug-likeness
0.185
Oral Bioavailability
13.3350
H-Bond Acceptors
15
H-Bond Donors
8
Rotatable Bonds
7
🔗 External References
10
Clinical Trials
7
Meta-Analyses
24
PubMed References
Top Conditions Studied with Hesperidin
Diabetes results from heterogeneous group of metabolic disor 1
Covid19|Anosmia|Fever|Cough|Shortness of Breath|Sore Throat| 1
Cardiovascular risk biomarkers. 1
Bioequivalence 1
arthritis, Alzheimer’s, cancer, cardiovascular disease, diab 1
Venous Insufficiency 1
Rheumatoid Arthritis 1
PreDiabetes 1
Osteoporosis, Postmenopausal 1
Systemic inflammation plays an important role in development 1
Osteoporosis, Osteopenia 1
insufficiency venous 1
📋 Sample Trials
NCT03737422
The Effects of Hesperidin and Flaxseed in Prediabetes
Completed · PreDiabetes
NCT03471910
Clinical Non-inferiority Study Between Diosmin 600mg & Diosmin + Hesperidin in Symptomatic Chronic Venous Insufficiency
Completed · Phase 4 · Venous Insufficiency
NCT05158192
Bioavailability of Diosmin/Hesperidin (90/10) 500 mg Tablets With Regards to Reference Product
Completed · Phase 1 · Bioequivalence
NCT00330096
Effects of Hesperidin on Bone Mineral Density and Bone Metabolism of Postmenopausal Women
Completed · Phase 3 · Osteoporosis, Osteopenia
NCT00545116
Effects of Hesperidin on Bone Biomarkers in Postmenopausal Women
Completed · Phase 2 · Osteopenia|Osteoporosis
NCT01881204
Hesperidin and Bone Health in Postmenopausal Women
Completed · Osteoporosis, Postmenopausal
📊 Sample Meta-Analyses
CRD42017078018
Systematic review and meta-analysis of efficacy of diosmin and hesperidin versus aminftones in inflammatory mediators levels decrease and pain scale in chronic venous insufficiency treatment.
insufficiency venous
CRD42017058859
Effects of hesperidin and orange juice supplementation on glycemic control: a systematic review and meta-analysis of clinical trials
Diabetes results from heterogeneous group of metabolic disorders which is closel
CRD42017059923
Effects of hesperidin and orange juice supplementation on inflammatory markers: a systematic review and meta-analysis of clinical trials
Systemic inflammation plays an important role in development of several chronic
CRD42017058191
The effect of hesperidin supplementation and orange juice on lipid profile and blood pressure: a systematic review and meta-analysis of clinical trials
Dyslipidemia and hypertension are known as a main risk factors for incidence of
CRD42018088942
Effects of hesperidin on cardiovascular risk biomarkers: a systematic review of animal and clinical studies
Cardiovascular risk biomarkers.
CRD42020162376
The impact hesperidin consumption from 100% orange juice has on chronic diseases: A systematic review and gap analysis
arthritis, Alzheimer’s, cancer, cardiovascular disease, diabetes, and osteoporos
📚 Sample References
PMID 25047426
Hesperidin induces apoptosis and triggers autophagic markers through inhibition of Aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis
Eur J Cancer · 2014
PMID 32522593
Neuroprotective effects of hesperidin against methotrexate-induced changes in neurogenesis and oxidative stress in the adult rat
Biochem Pharmacol · 2020
PMID 32655759
Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats
Oxid Med Cell Longev · 2020
PMID 32800830
Hesperidin protects against cadmium-induced pancreatitis by modulating insulin secretion, redox imbalance and iNOS/NF-ĸB signaling in rats
Life Sci · 2020
PMID 32916895
Yuzu and Hesperidin Ameliorate Blood-Brain Barrier Disruption during Hypoxia via Antioxidant Activity
Antioxidants (Basel) · 2020
PMID 32922291
The Anti-Depressive Effects of Hesperidin and the Relative Mechanisms Based on the NLRP3 Inflammatory Signaling Pathway
Front Pharmacol · 2020
🏥 Linked Health Topics 3 · matched via study conditions