Skip to content
AlternativeMed

How Acupuncture Is Explained: Traditional and Contemporary Views Side by Side

How acupuncture is explained in its traditional framework and in modern research, kept in separate layers: traditional idea, proposed mechanism, laboratory finding and clinical result.

Content last updated . This page has not been medically reviewed.

Four kinds of statement

People often mix very different kinds of claim when they say "how acupuncture works". This page keeps them apart:
  1. A traditional explanation: how the tradition itself describes health, illness and treatment.
  2. A proposed mechanism: an idea from modern researchers about what the needle might do in the body.
  3. A physiological finding: something measured in animals or people, such as a chemical released or a brain-imaging change.
  4. A clinical outcome: whether people's symptoms improved in a trial, and compared with what.

A finding in one layer does not prove the layer above or below it.

The traditional explanation

In East Asian medicine, acupuncture is embedded in naturalistic theories built on ideas such as yin and yang, qi, wind and dampness. A leading medical review describes these as conceptual frameworks that emphasize the reliability of ordinary human sensory awareness. It also notes that many physicians who practice acupuncture reject such prescientific notions. [1]

In this framework, qi (often translated as vital energy) is said to move along channels called meridians. The meridian system is described as consisting of 12 main channels, first set out in the Huangdi Neijing. [2] UNESCO's description of the practice says the theory holds that the body is connected by channels, and that stimulating them can promote self-regulating functions and bring health. [3]

Traditional practitioners also describe a needling sensation called deqi, literally "the arrival of vital energy". In theory it is a prerequisite for clinical effect. [4] Whether it predicts results is unsettled: a systematic review found few clinical studies, with conflicting results, and concluded the evidence was not solid enough to say. [5]

Respecting a tradition means describing it in its own terms. It does not mean treating qi or meridians as findings of anatomy. The research on whether points and meridians can be located is on do acupuncture points exist, and a fuller treatment of qi is on qi and acupuncture.

Authors differ on how much the classical writers knew of the body. One 2024 review argues the early authors had extensive anatomical and physiological knowledge, and says that offers clues to mechanisms. [6] A review of traditional Chinese medicine premises says anatomical study was relatively uncommon, and that many studies trying to find meridians anatomically do not meet current research-conduct guidelines. [2]

WHO's guidelines state that using acupuncture in modern medical care means taking it out of its traditional context and applying it as a technique, without having to reconcile traditional and modern theory. [7]

Proposed contemporary mechanisms

NCCIH says how acupuncture works is not fully understood, and describes three kinds of possible effect: on the nervous system, on local tissue, and nonspecific effects. [8] The rest of this section sorts the evidence for each.
Proposed mechanismWhat was actually measuredStrength of evidence
Nerves and natural pain-control chemicalsA review of mostly laboratory work describes opioid peptides as pivotal in acupuncture analgesia, with brain regions first found in animals later explored in people with imaging [9]Preclinical, with some human imaging
Adenosine near the needleAdenosine was released during acupuncture in mice, and its pain-relieving action needed adenosine A1 receptors [10]Preclinical
Pulling on connective tissueA hypothesis that needle rotation winds tissue around the needle and sends a mechanical signal to cells [11]. NCCIH says direct effects have been seen in connective tissue [8]Proposed, limited
Mu-opioid receptors in the brainIn people with fibromyalgia, real acupuncture raised opioid-receptor binding on PET scans, while sham did not [12]Physiological finding, one study
Nerve-controlled anti-inflammatory pathwayIn mice, electroacupuncture at the sciatic nerve reduced inflammation through vagus nerve signalling and adrenal dopamine [13]Preclinical
Expectation, belief and the therapeutic relationshipNCCIH lists belief and the practitioner relationship as nonspecific effects; imagining a past session produced pain relief in one study [8]Suggested by the pattern of trial results

A mechanism seen in mice does not show the same thing happens in people, or that it matters for any condition. The adenosine and vagal-adrenal papers are animal work, and the connective-tissue idea is a hypothesis.

What clinical trials add

A pooled analysis of individual data from 39 trials, covering 20,827 people with chronic musculoskeletal pain, osteoarthritis, headache or shoulder pain, found acupuncture better than sham by about 0.2 standard deviations and better than no acupuncture by about 0.5. The authors said pain relief could not be explained solely by placebo, and that factors beyond needling at the correct point locations contribute. [14]

Here is why that matters for the "how". The gap over no treatment is much larger than the gap over sham, and NCCIH says the pattern suggests nonspecific effects contribute. [8] A historical review also argues that some sham methods were chosen without checking whether they have physiological effects of their own, so sham comparisons may understate acupuncture's effects. [15] So neither "it is only placebo" nor "meridians have been proven" follows from the trials. See sham acupuncture and placebo controls.

What is established and what is not

  • Promising but limited: a modest effect on some chronic pain beyond sham, with part of the benefit from expectation and context. [14][8]
  • Preclinical or limited: specific chemical and nerve pathways. [10][13]
  • Insufficient evidence: that deqi, or points chosen by traditional theory, improve results. [5]
  • Not established: that qi or meridians exist as physical structures. [2]

For more, see how acupuncture may work: proposed mechanisms, brain imaging and neuroscience and the overview on what acupuncture is.

Frequently asked questions

How does acupuncture work?

Nobody knows for certain. Studies suggest effects on the nervous system and nearby tissue, plus expectation and context, while the traditional explanation uses qi and meridians. [8]

Is acupuncture just a placebo?

Probably not entirely. A pooled analysis of 39 trials found a benefit over sham for chronic pain, though a small one, and a larger gap over no treatment. [14]

Do meridians exist?

They are a traditional framework. A review of the evidence says many studies trying to find them anatomically do not meet current research-conduct guidelines. [2]

What is deqi?

Deqi is the needling sensation that traditional practitioners treat as the arrival of qi. Whether it predicts a better result has not been settled. [4][5]

Can an explanation be traditional and still be useful?

Yes. A tradition can offer a way of organizing care, and trials can still test whether a specific treatment helps. WHO says modern use does not require reconciling the theories. [7]

References
  1. Kaptchuk TJ, Acupuncture: theory, efficacy, and practice. Ann Intern Med. 2002. Abstract read 2026-10-22.
  2. Eigenschink M et al., Evidence underlying the basic concepts of traditional Chinese medicine. Wien Klin Wochenschr. 2020. Read 2026-10-22.
  3. UNESCO, Acupuncture and moxibustion of traditional Chinese medicine. Inscribed 2010. Read 2026-10-22.
  4. Li X et al., Deqi review. Evid Based Complement Alternat Med. 2013. Read 2026-10-22.
  5. Zhang S et al., Is deqi an indicator of clinical efficacy of acupuncture? A systematic review. Evid Based Complement Alternat Med. 2013. Read 2026-10-22.
  6. Dorsher P, The anatomical and physiological knowledge of the Huangdi Neijing authors: why it matters. Med Acupunct. 2024. Abstract read 2026-10-22.
  7. World Health Organization, Guidelines on basic training and safety in acupuncture. 1999. Read 2026-10-22.
  8. NCCIH, Acupuncture: Effectiveness and Safety. Last updated October 2022. Read 2026-10-22.
  9. Zhao ZQ, Neural mechanism underlying acupuncture analgesia. Prog Neurobiol. 2008. Abstract read 2026-10-22.
  10. Goldman N et al., Adenosine A1 receptors mediate local anti-nociceptive effects of acupuncture. Nat Neurosci. 2010. Abstract read 2026-10-22.
  11. Langevin HM et al., Mechanical signaling through connective tissue: a mechanism for the therapeutic effect of acupuncture. FASEB J. 2001. Abstract read 2026-10-22.
  12. Harris RE et al., Traditional Chinese acupuncture and placebo (sham) acupuncture are differentiated by their effects on mu-opioid receptors. Neuroimage. 2009. Abstract read 2026-10-22.
  13. Torres-Rosas R et al., Dopamine mediates vagal modulation of the immune system by electroacupuncture. Nat Med. 2014. Abstract read 2026-10-22.
  14. Vickers AJ et al., Acupuncture for chronic pain: update of an individual patient data meta-analysis. J Pain. 2018. Read 2026-10-22.
  15. Birch S et al., Historical perspectives on using sham acupuncture in acupuncture clinical trials. Integr Med Res. 2021. Read 2026-10-22.
Education, not medical advice. This page is for general information. It does not diagnose or treat any condition and is not a substitute for care from a qualified health professional. Natural does not automatically mean safe. Ask a clinician or pharmacist before changing your care, especially if you take medication, are pregnant or breastfeeding, or have a health condition.