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Each record is a registered study, a systematic-review registration or a publication. A registered or ongoing study is not a finding, and animal or cell research does not show an effect in people. The same study can appear under more than one subject, so the number of records is not a count of independent studies. You can also search an exact DOI, PubMed ID, NCT or CRD number. How to read these records.

12 study records (showing up to 30 per record type)

• Registered trial NCT05942352 Phase 4 Not completed: Recruiting
  Clinical Study of Ligustrazine in Treating Alcohol Addiction
  Condition or outcome area: Alcohol Abuse|Arteriosclerosis
  2023-07-28 · Subject: Chuanxiongzine; 2,3,5,6-Tetramethylpyrazine; 2,3,5,6-tetramethyl-pyrazine; CS-W023183; ZINC4042; 2,3,5,6-Tetramethyl-pyrazine; MolPort-002-473-658; N1918; 93615-56-6; Pyrazine, 2,3,5,6-tetramethyl- · open the ingredient record · ClinicalTrials.gov
• Systematic review registration CRD42023403863 Registered protocol, no results here: Review Ongoing
  Pregnancy risks of 30 pregnancy-related Chinese herbs: A systematic review and risk evaluation
  2023-05-09 · Subject: Chuan Xiong; 川芎; Szechwan Lovage Rhizome; Chuanxiong Rhizome, Szechuan Lovage Root; Rhizoma Chuanxiong; Chuanxiong Rhizoma
• Systematic review registration CRD42022380898 Registered protocol, no results here: Review Ongoing
  Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection as adjunctive therapy for acute ischaemic stroke: a systematic evaluation and meta-analysis
  Condition or outcome area: Ischemic stroke is the leading cause of death and disability among adults in China, characterized by high morbidity, disability, mortality, and recurrence rate.According to statistics, the age-standardized prevalence of stroke in China in 2013 was 1114.8 per 100, 000, with an incidence rate of 246.8 per 100, 000 and a mortality rate of 114.8 per 100, 000, An ongoing stroke surveillance programme covering 31 provinces in China reported an 8.3% annual increase in the incidence of first stroke in a
  2022-12-12 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42022334460 Registered protocol, no results here: Review Ongoing
  Efficacy and safety of ligustrazine injection in the treatment of hypertensive disease during pregnancy: a meta-analysis
  Condition or outcome area: Gestational hypertension is a disease that affects 5% to 10% of pregnant women worldwide and is associated with adverse fetal, neonatal and maternal outcomes such as placental abruption, premature delivery, stroke, disseminated intravascular coagulation and multiple organ (liver and kidney) failure, as well as adverse long-term cardiovascular health of women. Preexisting hypertension, gestational hypertension, preeclampsia, eclampsia, and HELLP syndrome. Ligusticum Chuanxiong, as a common medici
  2022-06-03 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42021288874 Registered protocol, no results here: Review Ongoing
  The Role and Mechanism of Ligustrazine for Atherosclerosis in Animal Models: A Meta-Analysis and Systematic Review
  2021-12-10 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42020193626 Registered protocol, no results here: Review Completed published
  Meta-analysis of clinical efficacy and safety of ligustrazine in the treatment of idiopathic pulmonary fibrosis
  Condition or outcome area: Idiopathic pulmonary fibrosis(IPF) is a different type of chronic progressive pulmonary interstitial inflammation and fibrosis with unknown etiology. Its histopathological process includes a series of processes, such as internal injury of epithelial cells, inflammatory exudation, myofibroblast formation, fibroblast aggregation and fibrosis scar formation, which lead to irreversible pathological changes of lung tissue structure. The thoracic HRCT will show general interstitial pneumonia. The main
  2020-07-23 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42020170240 Registered protocol, no results here: Review Ongoing
  The efficacy and safety of ligustrazine in stroke.
  Condition or outcome area: Stroke is a common disorder. It is due either to blockage of an artery in the brain or to bleeding in the brain. To improve the cerebral circulation, ligustrazine can protect the brain injury caused by cerebral ischemia-reperfusion. It also can reduce the injury of neurons and microvascular endothelial cells. This Meta-anlysis is to assess the efficacy and safety of ligustrazine in stroke.
  2020-04-28 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42020164851 Registered protocol, no results here: Review Ongoing
  Clinical efficacy and safety of Salvia ligustrazine injection for the treatment of vertebral-basilar insufficiency for a meta-analysis and systematic review
  Condition or outcome area: Since the introduction of the term vertebrobasilar insufficiency in 1946, it has been devoted to its clinical and pathological research.Vertebralbasilar insufficiency, also known as vertebral basilar artery transient cerebral ischemia, is generally mainly due to vascular malformations, hypertension, atherosclerosis Ischemia of the brain stem, cerebellum or occipital cortex due to vertebral basilar artery stenosis or occlusion caused by chemotherapy, hyperlipidemia, diabetes, smoking, etc.Insuffi
  2020-04-28 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42020163628 Registered protocol, no results here: Review Ongoing
  Effects and potential mechanism(s) of ligustrazine for the treatment of diabetic nephropathy: A Preclinical Systematic Review and Meta-analysis
  2020-01-19 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42018105921 Registered protocol, no results here: Review Completed not published
  The clinical efficacy of tanshinol combined with ligustrazine in the treatment of stable angina: a systematic review and meta-analysis
  Condition or outcome area: Stable angina refers to the classic type of angina related to myocardial ischemia. It is caused by a stable plaque that has not ruptured, but instead is producing a partial, fixed blockage in a coronary artery. This meta-analysis seeks to assess the effectiveness and safety of tanshinol combined with ligustrazine in the treatment of stable angina.
  2018-08-17 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42012003285 Registered protocol, no results here: Review Ongoing
  Ligustrazine for diabetic kidney disease
  Condition or outcome area: Diabetic nephropathy is typically defined by albuminuria and abnormal renal function as represented by abnormality in blood urea nitrogen (BUN) and serum creatinine(SCr). Clinically, DN is characterized as high risk of cardiovascular morbidity and mortality.
  2012-11-21 · Subject: Tetramethylpyrazine; 2,3,5,6-Tetramethylpyrazine; 1124-11-4; Ligustrazine; Pyrazine, tetramethyl-; Bs factor; Tetrapyrazine; Tetramethylpyrazin; Chuanxiongzine; Liqustrazine · open the ingredient record
• Systematic review registration CRD42020193978 Registered protocol, no results here: Review Ongoing
  Rhizoma Chuanxiong based-Chinese Medicine Therapy for Taxanes-Induced Peripheral Neurotoxicity：A Systemic Review and Meta-Analysis
  Condition or outcome area: Taxanes-derived agents such as paclitaxel and docetaxel are chemotherapy drugs widely applied in many types of cancers such as non-small cell lung cancer, metastatic breast cancer and ovarian cancer, and usually used as the first-line treatment. However, Peripheral neurotoxicity is the dose-limiting adverse effect of taxanes, limits its clinical administration, often manifested as painful neuropathy, compromise the quality of the survivorship, and it is sometimes irreversible.The incidence of ta
  2020-07-25 · Subject: Xi Chuan Xiong; 西川芎; Chuanxiong Rhizome, Szechuan Lovage Root; Radix Chuanxiong; Rhizoma Chuanxiong · open the herb record